This volume contains the proceedings of the 12th Italian Workshop on Neural Nets WIRN VIETRI-Ol, jointly organized by the International Institute for Advanced Scientific Studies "Eduardo R. Caianiello" (IIASS), the Societa Italiana Reti Neuroniche (SIREN), the IEEE NNC Italian RIG and the Italian SIG of the INNS. Following the tradition of previous years, we invited three foreign scientists to the workshop, Dr. G. Indiveri and Professors A. Roy and R. Sun, who respectively presented the lectures "Computation in Neuromorphic Analog VLSI Systems", "On Connectionism and Rule Extraction", "Beyond Simple Rule Extraction: Acquiring Planning Knowledge from Neural Networks" (the last two papers being part of the special session mentioned below). In addition, a review talk was presented, dealing with a very up-to-date topic: "Neuro Juzzy Approximator based on Mamdani’s Model". A large part of the book contains original contributions approved by referees as oral or poster presentations, which have been assembled for reading convenience into three sections: Architectures and Algorithms, Image and Signal Processing, and Applications. The last part of the books contains the papers of the special Session "From Synapses to Rules". Our thanks go to Prof. B. Apolloni, who organized this section. Furthermore, two sections are dedicated to the memory of two great scientists who were friends in life, Professors Mark Aizerman and Eduardo R. Caianiello. The editors would like to thank the invited speakers, the review lecturers and all the contributors whose highly qualified papers helped with the success of the workshop.