Comprehensive coverage of radical reactive intermediates in nucleic
acid chemistry and biochemistry
The Wiley Series on Reactive Intermediates in Chemistry and
Biology investigates reactive intermediates from the broadest
possible range of disciplines. The contributions in each volume
offer readers fresh insights into the latest findings, emerging
applications, and ongoing research in the field from a diverse
perspective.
The chemistry and biochemistry of reactive intermediates is
central to organic chemistry and biochemistry, and underlies a
significant portion of modern synthetic chemistry. Radical and
Radical Ion Reactivity in Nucleic Acid Chemistry provides the
only comprehensive review of the chemistry and biochemistry of
nucleic acid radical intermediates.
With contributions by world leaders in the field, the text
covers a broad range of topics, including:
* A discussion of the relevant theory
* Ionization of DNA
* Nucleic acid sugar radicals
* Halopyrimidines
* Oxidative, reductive, and low energy electron transfer
* Electron affinity sensitizers
* Photochemical generative of reactive oxygen species
* Reactive nitrogen species
* Enediyne rearrangements
* Phenoxyl radicals
A unique compilation on the cutting edge of our understanding,
Radical and Radical Ion Reactivity in Nucleic Acid Chemistry
provides an unparalleled resource to student and professional
researchers in such fields as organic chemistry, biochemistry,
molecular biology, and physical chemistry, as well as the
industries associated with these disciplines.
Innehållsförteckning
Preface to Series vii
Introduction ix
Contributors xi
1. Theoretical Modeling of Radiation-Induced DNA Damage 1
Anil Kumar and Michael D. Sevilla
2. Radical Reaction Pathways Initiated by Direct Energy
Deposition in DNA by Ionizing Radiation 41
William A. Bernhard
3. Chemical Reactions of the Radical Cations of Nucleobases in
Isolated and Cellular DNA. Formation of Single-Base Lesions
69
Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat,
and J. Richard Wagner
4. Reactivity of Nucleic Acid Sugar Radicals 99
Chryssostomos Chatgilialoglu
5. Pyrimidine Nucleobase Radical Reactivity 135
Marc M. Greenberg
6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163
Ryu Tashiro and Hiroshi Sugiyama
7. Kinetics of Long-Range Oxidative Electron Transfer Through
DNA 191
Kiyohiko Kawai and Tetsuro Majima
8. Radical Intermediates During Reductive Electron Transfer
Through DNA 211
Reji Varghese and Hans-Achim Wagenknecht
9. Low-Energy Electron Interaction with DNA: Bond Dissociation
and Formation of Transient Anions, Radicals, and Radical Anions
239
Leon Sanche
10. Electronic-Affinic Radiosensitizers 295
Peter Wardman
11. Reactions of Reactive Nitrogen Species and Carbonate Radical
Anions with DNA 325
Vladimir Shafirovich, Conor Crean, and Nicholas E.
Geacintov
12. Principles and Applications of Electrochemical Oxidation of
Nucleic Acids 357
H. Holden Thorp and Julie M. Sullivan
13. DNA Damage Due to Diradical-Generating Cyclizations
389
Sean M. Kerwin
14. DNA Damage by Phenoxyl Radicals 421
Richard A. Manderville
Index 445
Om författaren
Marc M. Greenberg is a Professor of Chemistry and Director
of the Chemistry Biology Interface Graduate Training Program at
Johns Hopkins University. His research uses chemistry,
biochemistry, and biology to fundamentally understand how DNA is
oxidatively damaged, and what the effects of that damage are.
Steven E. Rokita, Ph D, is Professor in the Department of
Chemistry and Biochemistry at the University of Maryland. His
research interests lie in sequence and conformation specific
reactions of nucleic acids, enzyme-mediated activation of
substrates and coenzymes, halogenation and dehalogenation reactions
in biology, aromatic substitution and quinone methide generation in
bioorganic chemistry, and copper- and nickel-mediated reactions in
bioinorganic chemistry.
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