The tiny micro RNAs (mi RNAs) can have huge impacts on the regulation of a variety of genes and play crucial roles in the fundamental cellular processes. Recent mi RNA studies change the landscape of cancer genetics by scrutinizing the alterations of genome-wide mi RNA expressions in most common cancers and their regulatory functions during the development of cancer. The connections between mi RNAs and cancer are widespread enough to warrant more comprehensive investigations in the systems biology perspective. In Micro RNA and Cancer: Methods and Protocols, internationally renowned experts provide the latest mi RNA knowledge, the various techniques and methodologies currently available for cancer research application. Ranging from the fundamental concepts to practical applications, this book presents: Overview of micro RNA biogenesis, computational prediction of new mi RNAs in the cancer genome, and mi RNA-based therapeutic approaches for cancer treatment Detailed experimental protocols in mi RNA detection with novel and high-throughput technology, mi RNA library cloning, mi RNA epigenetic regulation, and mi RNA pathway study Stepwise computational and bioinformatic procedures for mi RNA complex networks in cancer genomes with a variety of softwares and programs Cross-cited notes on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge, Micro RNA and Cancer: Methods and Protocols serves researchers with the basic principles of experimental and computational methods for micro RNA study in cancer research and provides a firm grounding for those who wish to further develop their own applications and tailor them to their own specific research needs.
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