Studying people’s lives requires acknowledging the multiple entanglements between individual singularity and processes of social patterning. This book testifies how challenging and creative the study of these connections can be. It gathers international contributions that show, in imaginative ways, how a person’s life or specific domains of existence can be observed, tackled, and analysed across time. This volume reveals the potential of biographical research in the production of social theory, in the development of methodological innovation, in giving voice and protagonism to people, and in the understanding of the social unfolding of their lives. It is a testimony of a vibrant and youthful field, with a long tradition in social sciences, and with numerous connections with other study areas, namely the life course approach. The different chapters illustrate how the challenges posed by this type of research focused on the individual level of analysis are particular and what creative responses are required to continue analysing the link between biography and society. The chapters in this book were originally published as a special issue of the journal Contemporary Social Science.