This book constitutes the thoroughly refereed post-conference proceedings of the 4th International Conference on Intelligence Science and Big Data Engineering, ISc IDE 2013, held in Beijing, China, in July/August 2013. The 111 papers presented were carefully peer-reviewed and selected from 390 submissions. Topics covered include information theoretic and Bayesian approaches; probabilistic graphical models; pattern recognition and computer vision; signal processing and image processing; machine learning and computational intelligence; neural networks and neuro-informatics; statistical inference and uncertainty reasoning; bioinformatics and computational biology and speech recognition and natural language processing.