Discover the link between the latest chemical biology approaches
and novel drug therapies!
Protein Targeting with Small Molecules: Chemical Biology
Techniques and Applications takes readers beyond the use of
chemical biology in basic research, providing a highly relevant
look at techniques that can address the challenges of biology and
drug design and development.
This indispensable bench companion features up-to-date coverage
of advances in chemistry and assesses their impact on developing
new therapeutics, making it ideal for chemical biologists and
medicinal chemists who are developing small molecule drugs to
target proteins and treat diseases. In addition, the book examines
the full range of complex biological systems and their
interrelationship with chemistry, from the interaction of
biological response modifiers with proteins to the chemical biology
of cell surface oligosaccharides.
Distinguished by an overview of chemical biology that is
reinforced and clarified by detailed examples and descriptions of
techniques, Protein Targeting with Small Molecules: Chemical
Biology Techniques and Applications:
* Introduces key technologies and methods of chemical biology
designed to detect the interactions of small molecules and
proteins
* Facilitates the discovery of small molecules that bind to
proteins and describes the molecules’ application in the
investigation of biological processes
* Presents timely coverage of the development of fluorescent
probes for small molecules, as well as the generation of small
molecule ligands and inhibitors
* Reviews important techniques such as chemical genomics, target
profiling, immobilization technology, detection methods, chemical
inhibition, and structure-based targeting
* Offers a compelling synopsis of data that underscores the
recent progress made in the area of targeting proteins by small
molecules
สารบัญ
Contributors.
Preface.
Chapter 1: Chemical biology based on the small molecule-protein
interaction (Hiroyuki Osada).
Chapter 2: Target Profiling of Small Molecules (Leonid L.
Chepelev, and Michel Dumontier).
Chapter 3: Novel application of affinity beads (Yasuaki Kabe,
Mamoru Hatakeyama, Satoshi Sakamoto, Kousuke Nishio, and Hiroshi
Handa).
Chapter 4: Immolization of small molecules on solid phase
(Naoki Kanoh, and Hiroyuki Osada).
Chapter 5: Application of phage display technique to identify
the target protein (Yoon Sun Cho and Ho Jeong Kwon).
Chapter 6: Development of fluorescent probes for small molecules
(Adrian P. Neal, and Carsten Schultz).
Chapter 7: Development of small molecule ligands and inhibitors
(Leonid L. Chepelev, Nikolai L. Chepelev, Hooman Shadnia,
William G. Willmore, James S. Wright, and Michel
Dumontier).
Chapter 8: Interaction of biological response modifier with
proteins (Yuichi Hashimoto).
Chapter 9: Chemical biology of cell motility inhibitors
(Tatsuro Kawamura, Mitsuhiro Kitagawa, and Masaya
Imoto).
Chapter 10: Chemical biology of cell surface oligosaccarides
(Prabhani U. Atukorale, Sean S. Choi, Udayanath Aich,
Christopher T. Campbell, M. Adam Meledeo, and Kevin J.
Yarema).
Chapter 11: Chemical genomics based on yeast genetics
(Shinichi Nishimura, and Yoko Yashiroda Minoru Yoshida).
Chapter 12: Data Fact of small molecules and their target
proteins (Takeo Usui, Akiko Saito, and Hiroyuki Osada).
Index.
เกี่ยวกับผู้แต่ง
Hiroyuki Osada is the Director and Chief Scientist in the Chemical Biology Department of RIKEN Advanced Science Institute and he is heading the RIKEN Natural Products Depository, RIKEN NPDepo. He is a former research fellow at the National Cancer Institute of the NIH. Dr. Osada is on the advisory boards of ACS Chemical Biology and Chemistry: An Asian Journal. In addition, he is an editorial member of four other journals, including Journal of Antibiotics and Journal of Microbiology and Biotechnology.
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