This book constitutes the refereed proceedings of the 10th International Rule ML Symposium, Rule ML 2016, held in New York, NY, USA during July 2016.The 19 full papers, 1 short paper, 2 keynote abstracts, 2 invited tutorial papers, 1 invited standard paper, presented were carefully reviewed and selected from 36 submissions. Rule ML is a leading conference aiming to build bridges between academia and industry in the field of rules and its applications, especially as part of the semantic technology stack. It is devoted to rule-based programming and rule-based systems including production rule systems, logic programming rule engines, and business rule engines and business rule management systems, Semantic Web rule languages and rule standards and technologies, and research on inference rules, transformation rules, decision rules, and ECA rules.