Junhua Tao & Romas Joseph Kazlauskas 
Biocatalysis for Green Chemistry and Chemical Process Development [PDF ebook] 

This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials.

The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.

สารบัญ

Contributors vii

Preface xi

Part I. Introduction Chapters 1

1. Biotechnology Tools for Green Synthesis: Enzymes, Metabolic
Pathways, and Their Improvement by Engineering 3

2. How Green Can the Industry Become with Biotechnology? 23

3. Emerging Enzymes and Their Synthetic Applications 45

4. Reaction Efficiencies and Green Chemistry Metrics of
Biotransformations 67

Part II. Application and Case Studies-Pharmaceuticals and
Fine Chemicals 89

5. Biocatalytic Routes to Chiral Intermediates for Development
of Drugs 91

6. Transglutaminase for Protein Drug Modification: Pegylation
and Beyond 151

7. Microbial Production of Plant-Derived Pharmaceutical Natural
Products Through Metabolic Engineering: Artemisinin and Beyond
173

8. Toward Greener Therapeutic Proteins 197

Part III. Application and Case Studies-Flavor &
Fragrance, Agrochemicals and Fine Chemicals 221

9. Opportunities for Biocatalysis in the Flavor, Fragrance, and
Cosmetic Industry 223

10. Application of Biocatalysis in the Agrochemical Industry
255

11. Green Porduction of Fine Chemicals by Isolated Enzymes
277

12. Whole Cell Production of Fine Chemicals and Intermediates
299

Part IV. Application and Case Studies-Polymers and Renewable
Chemicals 327

13. Green Chemistry for the Production of Biodegradable,
Biorenewable, Biocompatible, and Polymers 329

14. Enzymatic Degradation of Lignocellulosic Biomass 361

15. Bioconversion of Nenewables-Plant Oils 391

16. Microbial Bioprocesses for industrial-Scale Chemical
Production 429

Index 469

เกี่ยวกับผู้แต่ง

JUNHUA (Alex) TAO is currently CEO of Metabomics, Inc. Prior
to that; he was the CSO of Elevance Renewable Sciences, and the
creator and head of the Biotransformations Group at Pfizer, where
he was also a core member of the API Development Team. He
co-authored over 60 publications including ‘Biocatalysis for
the Pharmaceutical Industry’ (Wiley, 2009) and co-invented
over 20 patents. In addition, he was the recipient of the Pfizer
Achievement Award, the Pfizer Green Chemistry Award, and a key
member of the Lyrica process development team, which won the
IChem E Award for Excellence in Green Chemistry and Engineering
(2006).

ROMAS JOSEPH KAZLAUSKAS is Professor of Biochemistry,
Molecular Biology and Biophysics at the Bio Technology Institute of
the University of Minnesota, Twin Cities. He is the coauthor of
over eighty papers and reviews, and the book Hydrolases in Organic
Synthesis. He also served as the co-chair of two Gordon Research
Conferences, one on biocatalysis and one on green chemistry.