Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis. The dramatic advances in knowledge of thrombosis/hemostasis and vascular biology since the first publication of Recent Advances in Thrombosis and Fibrinolysis, edited with Japanese colleagues, in 1991, have required extensive revision in order to highlight and review recent progress in the field. The editors also gratefully welcome the seven distinguished non Japanese authors, who, with their valuable contributions on subjects beyond the coverage by Japanese authors, have made this new edition truly international.
สารบัญ
Coagulation Mechanism.- Structure and Functions of Fibrinogen and Fibrin.- Vitamin K Cycles and ?-Carboxylation of Coagulation Factors.- Synthesis and Secretion of Coagulation Factor VIII.- Structure and Biological Function of Factor XI.- Structural Insights into the Life History of Thrombin.- A Molecular Model of the Human Prothrombinase Complex.- Lipid Mediators and Tissue Factor Expression.- Tissue Factor Pathway Inhibitor: Structure and Function.- Biology of an Antithrombotic Factor—ADAMTS13.- Antithrombin and Heparin Cofactor II: Structure and Functions.- Endothelial Cells and Inflammation.- High-Mobility Group Box 1: Missing Link Between Thrombosis and Inflammation?.- Coagulation, Inflammation, and Tissue Remodeling.- Structure and Function of the Endothelial Cell Protein C Receptor.- New Aspects of Antiinflammatory Activity of Antithrombin: Molecular Mechanism(s) and Therapeutic Implications.- Platelets.- Platelet Collagen Receptors.- Positive and Negative Regulation of Integrin Function.- GPIb-Related Signaling Pathways in Platelets.- Sphingosine 1-Phosphate as a Platelet-Derived Bioactive Lipid.- Polymorphisms of Platelet Membrane Glycoproteins.- Platelet Procoagulant Activity Appeared by Exposure of Platelets to Blood Flow Conditions.- Tissue Proteolysis.- Regulation of Cellular u PA Activity and Its Implication in Pathogenesis of Diseases.- Role of t PA in the Neural System.- Role of Fibrinolysis in the Nasal System.- Role of Fibrinolysis in Hepatic Regeneration.- Pathophysiology of Transglutaminases Including Factor FXIII.- Vascular Development and Regeneration.- A Linkage in the Developmental Pathway of Vascular and Hematopoietic Cells.- Atherosclerosis and Angiogenesis: Double Face of Neovascularization in Atherosclerotic Intima and Collateral Vessels in Ischemic Organs.- Hemorrhagic Diathesis.- Hemophilia A and Inhibitors.- von Willebrand Disease: Diagnosis and Treatment.- Other Topics of Thrombosis and Hemostasis.- Age-Related Homeostasis and Hemostatic System.- Molecular Evolution of Blood Clotting Factors with Special Reference to Fibrinogen and von Willebrand Factor.- Snake Venoms and Other Toxic Components Affecting Thrombosis and Hemostasis.- Structures and Potential Roles of Oligosaccharides in Human Coagulation Factors and von Willebrand Factor.- Clinicals: Thrombosis-related Disorders and Recent Topics.- Hypercoagulable States.- Etiopathology of the Antiphospholipid Syndrome.- Malignancy and Thrombosis.- Disseminated Intravascular Coagulation.- Current Clinical Status of Venous Thromboembolism in Japan.- Platelet Activity and Antiplatelet Therapy in Patients with Ischemic Stroke and Transient Ischemic Attack.- Clinical Role of Recombinant Factor Vlla in Bleeding Disorders.- Clinical Role of Protein S Deficiency in Asian Population.- Atherothrombosis and Thrombus Propagation.- Thrombotic Microangiopathy.
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