In this compilation, the authors review the available evidence of the benefits of benfotiamine administration, paying particular attention to patients with type 2 diabetes mellitus and diabetic peripheral neuropathy, cardiac autonomic neuropathy and gastrointestinal neuropathy. An overview of cyclic AMP response element binding protein’s structure and functions is provided, in addition to a review of its molecular mechanisms and role in disease processes, including neural diseases, diabetes and cancer. Based on bibliographic references and studies carried out by the authors, this work also assesses the problem of modular total hip prostheses, regarded as a closed loop biotribosystem. The best available evidence in the field of dental rehabilitation is discussed, with the goal of constructing a reliable base for the approach of new investigations. In closing, the authors present the synthesis methods and pharmacological properties of triazole-derived heterocyclic systems. Triazoles are an important class of heterocyclic compounds that are five-membered aromatic azole ring with three nitrogen and two carbon atoms.
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