Cytokine and Chemokine Networks in Cancer’ provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
สารบัญ
Chapter 1_ Introduction to Cancer.- Chapter 2_ Expression pattern of Chemokines in Cancer.- Chapter 3_ Implications of Cytokine-Chemokine Heterogenity in Cancer.- Chapter 4_ Cytokine and chemokines networks in cancer stemness.- Chapter 5_ Cytokine and chemokines networks in angiogeneis.- Chapter 6_ Role of Cytokine-Chemokine cascades in Epithelial to Mesenchymal Transition.- Chapter 7_ Role of Chemokines in establishment of Metastatic Niche.- Chapter 8_ CXCL12-CXCR4 axis in Metastasis.- Chapter 9_ Chemokine and cytokine networks in the tumor microenvironment.- Chapter 10_ CXCL9, CXCL10, CXCL11/CXCR3 axis and Immune Activation.- Chapter 11_ CXCL8-CXCR1/2 axis in cancer and inflammatory diseases.- Chapter 12_ Cytokine and Chemokine Networks in Therapeutic Resistance.- Chapter 13_ Prognostic and diagnostic significance of Chemokines and cytokines in cancer.- Chapter 14_ Therapeutic implications of Chemokines and cytokines networks in cancer.- Chapter 15_ Chemokines in cancer therapy.
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Dr. Manzoor Ahmad Mir holds Master’s Degree in Zoology with Gold Medal from HNBG Central University and after qualifying prestigious National level CSIR-JRF-NET examination; got his Ph. D from Jawaharlal Nehru University New Delhi and CSIR-Institute of Microbial Technology Chandigarh in the field of Immunopathology. His research interest is Cancer Biology with specialization in Drug repurposing and combination therapy of breast cancer and to elucidate the molecular mechanism behind it, besides use of natural agents in treating cancer. He is also working on expression pattern and prognostic significance of chemokines/cytokines of CDKs in breast cancer besides virtual screening of drugs for cancer treatment and their mechanistic elucidation. He has published more than 50 high-impact research papers and book chapters, in recognition of which he has received several awards and Royalties from international publishing houses. Dr. Manzoor has authored more than 16 books with internationalpublishers like Elsevier USA and Nova Science Publisher USA, Bentham Sciences, IGI Global, Springer-Nature to name a few. He is on the editorial board and Reviewer of some prestigious journals and has been an invited speaker at various scientific meetings/conferences within India and abroad. He is member of many scientific organizations and societies like American Association of Cancer Research, Fellow of Royal British Society, American Association of Clinical Oncology, International Immunology Association, etc. Dr Manzoor was awarded Teachers Associate Research Excellence Fellowship (TARE) by DST Govt of India and Summer Research Fellowship Programme (SRFP-2019) by Indian Academy of Sciences and National Science Academy. Dr Manzoor has developed Massive Open Online Course (MOOCs) in Immunology, Human Genetics and Endocrinology for UG students sanctioned by UGC-Consortium for Educational Communication (CEC) SWAYAM Ministry of HRD Govt of India. He has research and teaching experience of 15 years in Cancer Biology, Animal cell and Tissue Technology, Molecular Modelling and Drug Design, Comparative Immunology. He currently teaches Cancer Biology, and Immunology at the Department of Bioresources, School of Biological Sciences, University of Kashmir. He is presently heading the Department of Bioresources, University of Kashmir.
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