Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume is focused on immunopathology of cancers. The interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the most recent research and new developments in the field. Over the past decade, understanding of the interactions between the immune system and cancerous cells has increased markedly, leading to the development of combinatorial immunotherapeutic strategies to combat cancer. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists and oncologists.
สารบัญ
Introduction on cancer immunology and immunotherapy.- Inflammatory and innate immune cells in cancer microenvironment and progression.- Role of innate immunity in cancers and antitumor response.- Role of B cells in anti tumor response.- The role of exhaustion in tumor-induced T cell dysfunction in patients with cancer.- Regulatory T cells and Th17 cells in the immunosuppressive tumor network.- Role of cytokines in tumor immunity and immune tolerance to cancers.- Role of chemokines and chemokine receptors in cancers.- The role of Fas and Fas-ligand in cancers.- MHC class I molecules and cancer progression: Lessons learned from preclinical tumor models.- Role of plasmacytoid dendritic cells in cancer.- Cancer immunoediting: immunosurveillance, immuneequilibrium, and immune escape.- Apoptosis, autophagy and necroptosis in Cancer.- Prognostic value of innate and adaptive immunity in cancers.- Epigenetics and Micro RNAs in cancers .- Immunogenetics of cancers.- Immunodeficiencies and cancers.- Immunosenescence and cancers.- Nutrition, immunity and cancers.- Allergies and cancers.- Cancer immunology of transmissible cancers.- Systems biology and systems immunology of cancer.- Principles of immunological diagnostic tests for cancers.- Flow cytometry in cancer immunotherapy: applications, analysis, quality control and future.- Immunohistochemistry of cancers.- Immunology and immunotherapy of graft versus host disease.
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Nima Rezaei gained his medical degree from Tehran University of Medical Sciences and Health Services in 2002 and subsequently obtained MSc in Molecular and Genetic Medicine and Ph D in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Since 2010, Dr. Rezaei has worked at the Department of Immunology, School of Medicine, Tehran University of Medical Sciences; he is also the Chief Executive Director of the Children’s Medical Center Hospital, Tehran and a co-founder and Deputy President of the Research Center for Immunodeficiencies. In addition, Dr. Rezaei is an Honorary Research Fellow at the Department of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield. Dr. Rezaei has already been the Director of more than 50 research projects and has designed and participated in several international collaborative projects. Dr. Rezaei is an editorial assistant or board member for more than 20 international journals. He has published more than 400 articles in international scientific journals and edited ten further books.
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