This collection of essays examines the subject of power politics in Africa, paying special attention to the interests of African regional powers, as well as their capabilities and strategies in the international arena. It provides a theoretical bridge between concerns for militarised national interest, perpetual distrust and insecurity, struggles for power and hegemony in power politics, and the spirit of pan-African solidarity, brotherhood, consensus, cooperation and integration. It is on these bases that this volume offers rich empirical insight into leading regional powers in Africa with special attention given to Nigeria and South Africa. It serves to contribute African perspectives to the field of International Relations, particularly regarding power politics, which is important in terms of Africanising the narratives of a subject matter that is largely considered as Eurocentric in African and other non-Western societies.