This book provides insights into the recent developments in the field of bioprocess technology and bioreactor design. Bioprocess engineering or biochemical engineering is a subcomponent of chemical engineering, which encompasses designing and developing those processes and equipment that are required for the manufacturing of products from biological materials and sources, such as agriculture, pharmaceutical, chemicals, polymers, food, etc., or for the treatment of environmental process, for example, waste water. The main focus of this book is to highlight the advancements in the field of bioprocess technology and bioreactor design. The book is divided into various chapters briefing all aspects of bioprocess engineering and focusing on the advances in bioprocess engineering. The book summarizes introduction to bioprocess technology and microbiology, isolation and maintenance of microbial strains, and sterilization techniques for advanced-level students and researchers. Different models depicting kinetics of microbial growth, substrate consumption, and product formation are discussed. The applications of enzymes have increased tremendously and therefore understanding their metabolic pathways to increase yields is also briefly discussed. The calculations of mass and energy balances associated with entropy changes and free energy. This book also covers the approaches for handling different types of cell cultures and current advancements in the area of bioprocess strategies for different culture types, which scientists and researchers working in the different cell cultures can refer to. The downstream processing of various industrially important products is also a part of this book. Apart from that, the process economics which ensures the feasibility and quality of any biological process is also dealt with as the last section of the book.
สารบัญ
Chapter 1: Introduction to bioprocess technology.- Chapter 2: Understanding the metabolic pathways to increase the product yield.- Chapter 3: Metabolic Engineering of Lipid Biosynthesis Pathway to Enhance the Oil Content in Microalgae.- Chapter 4: Basic Concepts and Applications of Enzyme catalyzed reactions for Biotechnology.- Chapter 5: Kinetics of microbial growth, substrate consumption, and product formation.- chapter 6: Bioreactor configurations for fermentation processes.- Chapter 7: Downstream processing for bioproduct recovery and purification.- Chapter 8: Principles of Basic and advanced techniques used for the purification of enzymes of industrial importance.- Chapter 9: Bioprocess Strategies for the Production of Short-Chain Organic Acids from Microbial Cells.- Chapter 10: Metabolic burden analysis in in-vitro culture of plants: A bioprocess strategy for efficient process design.- Chapter 11: Advances In Bioreactor Design for Plant Cell Culture.- Chapter 12: Economics of fermentation processes.- Chapter 13 Economics of Fermentation Processes.
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Dr. Swasti Dhagat is a Scientist at Society for Research and Initiatives for Sustainable Technologies and Institutions (SRISTI). She did her Ph.D. in Biotechnology from National Institute of Technology (NIT) Raipur and M.Tech in Biotechnology from Birla Institute of Technology and Science (BITS)-Pilani, Hyderabad. She has published 17 scientific articles in international peer-reviewed journals, one conference proceedings in international conference, four book chapters and two books. She is currently handling one research project sponsored by government body with many internal projects. She is serving as an Editorial Member of Edwin Group of Journals. Her research area focuses on applied microbiology especially in the area of agriculture, soil microbiology and bioprocess and bioproduct development. Dr. J. Satya Eswari is currently an Assistant professor from more than 8 years at Department of Biotechnology, National Institute of Technology (NIT) Raipur, India. She did her Ph.D.from IIT Hyderabad and M.Tech in Biotechnology from Indian Institute Technology (IIT) Kharagpur. During her research career, she worked as a Scientist (woman scientist- Department of science and technology (DST)) in the Indian Institute of Chemical Technology (IICT) Hyderabad. She has published more than 70 SCI/Scopus research papers, 6 books, few book chapters, and 40 publications in international conference proceedings. Her research contributions have received wide global citations. She completed 3 projects sponsored by various government agencies. She has teaching experience more than 10 years and 3 years of research experience. She has been Guest editor She has rigorously pursued her research in the areas of Environmental bioremediation, wastewater treatment, bioprocess and product development and bioinformatics. She gained pioneering expertise in the application of mathematical and engineering tools to Biotechnological processes. She has received IEI young engineer award, outstanding woman scientist by Venus international and DK Best faculty award. She has supervised 5 Ph.D. students and is currently guiding 1 Ph.D. student while also serving as a co-supervisor for two additional Ph.D. students.
Dr. N.S. Sampath Kumar is working as Associate Professor in the Department of Biotechnology and concurrently acting as Joint Dean, Academics Assessment & Awards at Vignan’s Foundation for Science, Technology & Research, Vadlamudi, Andhra Pradesh, India. Earlier he served in various positions such as Associate Dean, Internal Quality Assurance Cell and Director, Slow Learners Supportive System. He obtained his Ph.D. in Biotechnology from SRM University, Tamil Nadu, India and Master’s degree from Acharya Nagarjuna University, Andhra Pradesh, India. Cumulatively, he has 16 years of teaching and research experience, and extensively working in the area of ‘Biomaterials and bioactive compounds’. He has published more than 52 peer-reviewed articles and reviews in various international journals, Dr. Sampath has also published a good number of book chapters with reputed publication house Patent authority of India has granted him patent rights for his work on ‘An edible flavor enhancer from Pterygoplichthys pardalis’ and a couple of other patents are lined-up. He is presently handling a DST Project entitled “STI Hub for Income Generation and Livelihood Improvement of Scheduled Caste community of Guntur District, Andhra Pradesh”, sanctioned under SEED division of STI Hub for SC Community scheme worth Rs.1, 60, 73, 660 ($ 215310.85 USD) as a Co-Principal Investigator. He has supervised 1 Ph.D. scholar and 4 more scholars are continuing their research work under his guidance. He is an Associate Fellow of A.P. Akademi of Sciences (APAS) and acting as reviewer for 17 prestigious international journals He was invited as session chair and resource person for several international and national conferences besides he has conducted several conferences and DST inspire camps.
Dr. Chinmaya Mahapatra is currently working as an Assistant Professor at the Department of Biotechnology, National Institute of Technology (NIT) Raipur. He did his Ph D from Institute of Tissue Regeneration Engineering (ITREN) South Korea under BK (Brain Korea) fellowship. His did his Post Doctoral training from the Indian Institute of Science, Bangalore and Helmholtz Zentrum Geesthacht, Berlin. Further he was awarded with National Research Foundation (NRF-KRF) research fellowship to work in Sungkyunkwan University (SKKU). His interest areas are Biomaterials, Nanotherapeutics, Anti-Fungal Materials, and Redox Nano-Materials based actuators.
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