This book constitutes the refereed proceedings of the 15th International Conference on Information Security Practice and Experience, ISPEC 2019, held in Kuala Lumpur, Malaysia, in November 2019. The 21 full and 7 short papers presented in this volume were carefully reviewed and selected from 68 submissions. They were organized into the following topical sections: Cryptography I, System and Network Security, Security Protocol and Tool, Access Control and Authentication, Cryptography II, Data and User Privacy, Short Paper I, and Short Paper II.