Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.
İçerik tablosu
General Overview.- Nitric Oxide and Cancer: An Overview.- Nitric Oxide and the Pathogenesis of Cancer.- A Role for e NOS in Oncogenic Ras-Driven Cancer.- Dual Role of Nitric Oxide in Cancer Biology.- Nitric Oxide Expression in Cancer.- Dual Roles of Nitric Oxide in Protecting or Inducing Cell Death.- S-Nitrosylation – How Cancer Cells Say NO to Cell Death.- Cytotoxic and Protective Activity of Nitric Oxide in Cancers.- Cytotoxic/Protective Activity of Nitric Oxide in Cancer.- Nitric Oxide and Life or Death of Human Leukemia Cells.- Inhibition of Apoptosis by Endogenous Nitric Oxide in Chronic Lymphocytic Leukaemia.- Role of Nitric Oxide in Metastasis.- Nitric Oxide: A Rate-Limiting Factor for Metastases Development.- Nitric Oxide Inhibits Tumor Cell Metastasis via Dysregulation of the NF-?B/Snail/RKIP Loop.- Nitric Oxide as a Sensitizing Agent for Chem-Radio-Immunotherapy.- Sensitizing Effect of Nitric Oxide to Cytotoxic Stimuli.- Nitric Oxide Is a Promising Enhancer for Cancer Therapy.- Role of Nitric Oxide for Modulation of Cancer Therapy Resistance.- Breaking Resistance: Role of Nitric Oxide in the Sensitization of Cancer Cells to Chemo- and immunotherapy.- Prognostic Significance of NOS and NO.- Prognostic Significance of i NOS in Human Melanoma.- Prognostic Significance of i NOS in Hepatocellular Carcinoma.- Prognostic Significance of i NOS in Esophageal Cancer.- Prognostic Significance of Nitrative DNA Damage in Infection- and Inflammation-Related Carcinogenesis.- Therapeutic Applications of Nitric Oxide.- Nitric Oxide-Releasing Molecules for Cancer Therapy and Chemoprevention.- Nitric Oxide: Monotherapy or Sensitiser to Conventional Cancer Treatments?.- Therapeutic Applications of Nitric Oxide for Malignant Tumor in Animal Models and Human Studies.-(S, R)-3-Phenyl-4, 5-dihydro-5-isoxazole acetic acid–Nitric Oxide (GIT-27NO) – New Dress for Nitric Oxide Mission.- Nitric Oxide Donors Are a New Class of Anti-cancer Therapeutics for the Reversal of Resistance and Inhibition of Metastasis.- Role of Inducible Nitric Oxide Synthase (i NOS) in Regulation of Nitric Oxide (NO) Production and Stabilization of HIF-1?: Potential Role of Se-Methylselenocysteine (MSC), an Antioxidant Multi-targeted Small Molecule.
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