Entrepreneurship is critical to economic growth, but it cannot flourish without open markets. Entrepreneurs can only be expected to take risks in ‘open settings’ where individuals and firms are free to contract with one another. In this important book, leading economists explain and document the role of open markets, within and across national boundaries, in facilitating entrepreneurship, innovation, and economic growth. The main message of this book is especially timely given growing concerns in developed countries about off-shoring and openness to trade. The book includes discussions of ‘star’ scientists-entrepreneurs and their positive impacts on local growth, the globalization of venture capital, information technology, entrepreneurship and cities, culture, off-shoring, trade competition and the expansion of world trade.This book will be welcomed by policy makers at all levels of government, university leaders and academic scholars in entrepreneurship, business and management, innovation, economics and sociology.