Our future depends on our collective ability to become effective stewards of the global commons – the climate, ice, land, ocean, fresh water, forests, soils and rich diversity of life. Hosted by the Nobel Foundation and organized by the US National Academy of Sciences in partnership with the Potsdam Institute for Climate Impact Research and the Stockholm Resilience Centre/Beijer Institute, the first Nobel Prize Summit brought together Nobel Prize laureates, scientists, policy makers, business leaders, and youth leaders to explore the question: What can be achieved in this decade to put the world on a path to a more sustainable, more prosperous future for all of humanity?From April 26-28, 2021, this virtual event combined keynotes and lively discussion with live performance and theatre. Framed around the United Nations’ Sustainable Development Goals, speakers explored solutions to some of humanity’s greatest challenges: climate change and biodiversity loss, increasing inequality, and technological innovation in support of societal goals. This publication summarizes the presentations and discussions of the Summit.