This volume contains the proceedings of the Eighth International Conference on Scientific Computing and Applications, held April 1-4, 2012, at the University of Nevada, Las Vegas. The papers in this volume cover topics such as finite element methods, multiscale methods, finite difference methods, spectral methods, collocation methods, adaptive methods, parallel computing, linear solvers, applications to fluid flow, nano-optics, biofilms, finance, magnetohydrodynamics flow, electromagnetic waves, the fluid-structure interaction problem, and stochastic PDEs. This book will serve as an excellent reference for graduate students and researchers interested in scientific computing and its applications.