The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver’s role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation.
The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs.
A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students.
İçerik tablosu
1. Core Concepts in Immunology: The Definition of Autoimmunity and Its Unique Application to the Seat of Tolerance, the Liver.- 2. The Liver as a Lymphoid Organ.- 3. The Uniqueness of Innate Immunity.- 4. Adaptive Immunity and the Clinical Definition of Autoantibodies.-5. Genetics of Autoimmune Liver Diseases.- 6. The Epigenetic Basis of Loss of Tolerance.- 7. Bile Acids and Bilirubin in Liver Immunology.- 8. The Microbiota-Gut-Liver Axis – Implications for the Pathophysiology of Liver Disease.- 9. Diagnostic Liver Immunology.- 10. The Pathologist’s Approach to Reviewing Liver Histology.- 11. Geoepidemiology of Autoimmune Liver Diseases.- 12. Immune Responses to Bacterial Infections.- 13. Immunity of Parasitic Infections of the Liver.- 14. The Treatment of Bacterial and Parasitic Diseases of the Liver.- 15. Hepatitis A and Other Viral Infections.- 16. Hepatitis B Virus.- 17. Hepatitis C.- 18. Hepatitis D.- 19. Hepatitis E.- 20. Alcohol-Associated Liver Disease.- 21. Non-alcoholic Fatty Liver Disease: A Chapter in Liver Immunology.- 22. Primary Biliary Cholangitis.- 23. PSC – AIH Overlap.- 24. Primary Biliary Cholangitis: Autoimmune Hepatitis Overlap Syndrome.- 25. Primary Sclerosing Cholangitis .- 26. Autoimmune Hepatitis.- 27. Ig G4-related Disease: Current Concept, Diagnosis, and Pathogenesis.- 28. Pediatric Liver Disease.- 29. Mechanisms of Acute Liver Failure.- 30. Immune-Mediated Drug-Induced Liver Injury.- 31. Hepatobiliary Cancers and Immunology.- 32. Acute-on-Chronic Liver Failure.- 33. The Pathogenesis of Liver Diseases in Pregnancy.- 34. Graft-Versus-Host Disease.- 35. Immunopathogenesis of Liver Cirrhosis.- 36. Immune-Mediated Liver Disease in the Transplanted Liver.
Yazar hakkında
M. Eric Gershwin, MD
Distinguished Professor of Medicine
The Jack and Donald Chia Endowed Professor University of California School of Medicine
Davis, CA
USA
John M. Vierling, MD
Professor of Medicine and Surgery
Chief of Hepatology
Director of Baylor Liver Health
Baylor College of Medicine
Houston, TX
USA
Atsushi Tanaka, MD, Ph D
Professor
Department of Medicine
Teikyo University School of Medicine
Tokyo, Japan
Michael P. Manns, MD
Professor and Department of Medicine Chair
Department of Gastroenterology, Hepatology, and Endocrinology Hannover Medical School
Hannover, Germany
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