Annual Reports in Medicinal Chemistry continues to focus on providing timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. – Annual comprehensive reviews of the past year literature in many topics of interest to medicinal chemists- Includes a comprehensive set of indices to easily locate topics in Volumes 1-38 of this series- Provides critical review on hot topics in medicinal chemistry