The aging process, especially in the skin, is governed by changes in the epidermal, dermal-epidermal and dermal compartments. Extracelluar matrix (ECM) proteins, which are the major component of dermis, constitute an important target for intrinsic and extrinsic aging related alterations. In this book, the authors present topical research in the study of skin aging including the effects of strenuous exercise on the aging skin; extracellular matrix proteins during skin aging; improved cell metabolism and strengthening of the extracellular matrix by nicotinamide and copper for anti-skin aging; skin morphology of Caucasian women during aging; molecular understanding of the development of age spots; and skin rejuvenation and ablative laser therapy.