This book constitutes the refereed proceedings of the 43rd DAGM German Conference on Pattern Recognition, DAGM GCPR 2021, which was held during September 28 – October 1, 2021. The conference was planned to take place in Bonn, Germany, but changed to a virtual event due to the COVID-19 pandemic.The 46 papers presented in this volume were carefully reviewed and selected from 116 submissions. They were organized in topical sections as follows: machine learning and optimization; actions, events, and segmentation; generative models and multimodal data; labeling and self-supervised learning; applications; and 3D modelling and reconstruction.