Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid. Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis. Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body. Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases. Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. This book is a required text for any researcher in the field of arterial chemoreception for years to come. It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.
Зміст
The Role of Hypoxia-Inducible Factors in Oxygen Sensing by the Carotid Body – Invited Article.- Neuronal Mechanisms of Oxygen Chemoreception: An Invertebrate Perspective – Invited Article.-
Peripheral Chemoreceptors in Air- versus Water- Breathers Invited Article.- Sex-specific Effects of Daily Gavage With a Mixed Progesterone and Glucorticoid Receptor Antagonist on Hypoxic Ventilatory Response in Newborn Rats.- Age-Dependent Changes in Breathing Stability in Rats.- Dose Dependant Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats.- Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization.- Erythropoietin and the Sex-Dimorphic Chemoreflex Pathway – Invited Article.- Time-course of Ventilation, Arterial and Pulmonary CO2 Tension During CO2 Increase in Humans.- Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex.- Ion channel regulation by the Lkb1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. – Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices.- Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells.- Acute Hypoxia Does Not Influence Intracellular ph in Isolated Rat Carotid Body Type I Cells.- Hydrogen Sulphide (H2S): A Physiologic Mediator Of Carotid Body Response To Hypoxia – Invited Article.- The Retrotrapezoid Nucleus and Breathing – Invited Article.-The Interaction Between Low Glucose and Hypoxia in the in vitro, Rat Carotid Body.- Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans?.- Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation.- CO2 Signaling in Chemosensory Neuroepithelial Cells of the Zebrafish Gill Filaments: Role of Intracellular Ca2+ and p H.- Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of Prolyl Hydroxylase -1(PHD-1) Deficient Mice.- Precision-cut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal Mice.- Oxygen Sensitivity of Gill Neuroepithelial Cells in the Anoxia-tolerant Goldfish.- Interaction of Hypoxia and Core Temperature: potential role of TRPV1.- Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats.- LPS-Induced c-Fos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats are Suppressed by Bilateral Carotid Chemodenervation.- Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells: Potential Role of the KATP Channel.- Contribution of Inflammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia.- Spexin is Expressed in the Carotid Body and is Upregulated by Postnatal Hyperoxia Exposure.- Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction between Hypoxia and Hypercapnia in the Carotid Body.225.- Interactions between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respiratory Function.- Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis after Carotid Chemoreceptor Stimulation in Rats.- Hydrogen Sulfide Acting at the Carotid Body and Elsewhere in the Organism.- Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats – Invited Article.- Serotonin Dynamics and Actions in the Rat Carotid Body: Preliminary Findings.- Human Carotid Body HIF and NGB Expression During Human Development and Aging.- Propranolol Does Not Affect the Hindlimb Vasodilatation Elicited by Stimulation of Superior Laryngeal Nerve Paraganglia.- ATP Release from the Carotid Bodies (CB) of DBA/2J and A/J Inbred Mouse Strains.- Effect of Oxygen on Phosphodiesterases (PDE) 3 and 4 Isoforms and PKA Activity in the Superior Cervical Ganglia.- Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat.- Upregulation of Pituitary Adenylate Cyclase Activating Polypeptide and its Receptor Expression in the Rat Carotid Body in Chronic and Intermittent Hypoxia.- Rabbit Ventilatory Responses to Peripheral Chemoexcitators: Effects of Chronic Hypoxia.-
Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats.- Effects of Cigarette Smoke and Chronic Hypoxia on Ventilation in Guinea Pigs. Clinical Significance.- Some Reflections on Intermittent Hypoxia. Does it Constitute the Translational Niche for Carotid Body Chemoreceptor Researchers?.- Role of Central / Peripheral Chemoreceptors and Their Interdependence in the Pathophysiology of Sleep Apnea – Invited Article.- Physiologic Basis for Intermittent Hypoxic Episodes In Preterm Infants.- Chronic Intermittent Hypoxia Increases Apnoea Index in Sleeping Rats.- Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia.- Antioxidation and the Hypoxic Ventilatory Response.- Differential Regulation of Tyrosine Hydroxylase by Continuous and Intermittent Hypoxia.- Heart Failure and Carotid Body Chemoreception.
Peripheral Chemoreceptors in Air- versus Water- Breathers Invited Article.- Sex-specific Effects of Daily Gavage With a Mixed Progesterone and Glucorticoid Receptor Antagonist on Hypoxic Ventilatory Response in Newborn Rats.- Age-Dependent Changes in Breathing Stability in Rats.- Dose Dependant Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats.- Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization.- Erythropoietin and the Sex-Dimorphic Chemoreflex Pathway – Invited Article.- Time-course of Ventilation, Arterial and Pulmonary CO2 Tension During CO2 Increase in Humans.- Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex.- Ion channel regulation by the Lkb1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. – Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices.- Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells.- Acute Hypoxia Does Not Influence Intracellular ph in Isolated Rat Carotid Body Type I Cells.- Hydrogen Sulphide (H2S): A Physiologic Mediator Of Carotid Body Response To Hypoxia – Invited Article.- The Retrotrapezoid Nucleus and Breathing – Invited Article.- The Interaction Between Low Glucose and Hypoxia in the in vitro, Rat Carotid Body.- Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans?.- Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation.- CO2 Signaling in Chemosensory Neuroepithelial Cells of the Zebrafish Gill Filaments: Role of Intracellular Ca2+ and p H.- Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of Prolyl Hydroxylase -1(PHD-1) Deficient Mice.- Precision-cut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal Mice.- Oxygen Sensitivity of Gill Neuroepithelial Cells in the Anoxia-tolerant Goldfish.- Interaction of Hypoxia and Core Temperature: potential role of TRPV1.- Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats.- LPS-Induced c-Fos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats are Suppressed by Bilateral Carotid Chemodenervation.- Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells: Potential Role of the KATP Channel.- Contribution of Inflammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia.- Spexin is Expressed in the Carotid Body and is Upregulated by Postnatal Hyperoxia Exposure.- Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction between Hypoxia and Hypercapnia in the Carotid Body.225.- Interactions between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respiratory Function.- Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis after Carotid Chemoreceptor Stimulation in Rats.- Hydrogen Sulfide Acting at the Carotid Body and Elsewhere in the Organism.- Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats – Invited Article.- Serotonin Dynamics and Actions in the Rat Carotid Body: Preliminary Findings.- Human Carotid Body HIF and NGB Expression During Human Development and Aging.- Propranolol Does Not Affect the Hindlimb Vasodilatation Elicited by Stimulation of Superior Laryngeal Nerve Paraganglia.- ATP Release from the Carotid Bodies (CB) of DBA/2J and A/J Inbred Mouse Strains.- Effect of Oxygen on Phosphodiesterases (PDE) 3 and 4 Isoforms and PKA Activity in the Superior Cervical Ganglia.- Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat.- Upregulation of Pituitary Adenylate Cyclase Activating Polypeptide and its Receptor Expression in the Rat Carotid Body in Chronic and Intermittent Hypoxia.- Rabbit Ventilatory Responses to Peripheral Chemoexcitators: Effects of Chronic Hypoxia.-
Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats.- Effects of Cigarette Smoke and Chronic Hypoxia on Ventilation in Guinea Pigs. Clinical Significance.- Some Reflections on Intermittent Hypoxia. Does it Constitute the Translational Niche for Carotid Body Chemoreceptor Researchers?.- Role of Central / Peripheral Chemoreceptors and Their Interdependence in the Pathophysiology of Sleep Apnea – Invited Article.- Physiologic Basis for Intermittent Hypoxic Episodes In Preterm Infants.- Chronic Intermittent Hypoxia Increases Apnoea Index in Sleeping Rats.- Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia.- Antioxidation and the Hypoxic Ventilatory Response.- Differential Regulation of Tyrosine Hydroxylase by Continuous and Intermittent Hypoxia.- Heart Failure and Carotid Body Chemoreception.
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