Dieter Marmé & Norbert Fusenig 
Tumor Angiogenesis [PDF ebook] 
Basic Mechanisms and Cancer Therapy

Historical Overview.- Tumor Angiogenesis: from Bench to Bedside.- Mechanisms.- Vasculogenesis and Angiogenesis in Development.- Guidance of Vascular and Neuronal Network Formation.- The Angiogenic Switch in Tumorigenesis.- Pathophysiology and Clinical Implications of Vascular Endothelial Growth Factor.- Regulation of Angiogenesis and Vascular Homeostasis Through the Angiopoietin / Tie System.- Eph Receptors and Ephrins: Role in Vascular Development and Tumor Angiogenesis.- The Role of the Neuropilins and Their Associated Plexin Receptors in Tumor Angiogenesis and Tumor Progression.- Platelet-derived Growth Factor: Impact on Physiological and Tumor Angiogenesis.- Hypoxia and Tumour Angiogenesis.- Hypoxia and Angiogenesis in Glioblastomas.- Endogenous Inhibitors of Angiogenesis.- Thrombospondins and Angiogenesis.- Molecular and Cellular Aspects of Heparanase.- Vessel Maturation and Perivascular Cells.- Adhesion Molecules in the Vascular Cell Cross-Talk.- Homing and Differentiation of Endothelial Progenitor Cells.- Molecular Players in Lymphangiogenesis.- The Relationship Between Tumors and the Lymphatics: Consequences for Metastasis.- Inflammation and Angiogenesis: Innate Immune Cells as Modulators of Tumor Vascularization.- Arteriovenous Malformation in Mice and Men.- Animal Models and Preclinical Anti-Angiogenic Studies.- Vascular Endothelial Growth Factor Antibodies for Anti-Angiogenic Therapy.- Vascular Endothelial Growth Factor.- Vascular Endothelial Growth Factor Receptor Antibodies for Anti-Angiogenic Therapy.- Angiopoietin-2 Antagonists for Anti-Angiogenic Therapy.- Anti-Angiogenic Therapy with Thrombospondins.- The Use of Orthotopic Models to Validate Antivascular Therapies for Cancer.- Vascular Tumor Targeting.- Molecular Imaging of Targets and Therapeutics in Tumour Angiogenesis.- Imaging of Tumor Angiogenesis and Antiangiogenesis.- Visualization of Microcirculation and Anti-Angiogenic Tumor Therapy.- Cellular Actions of Angiogenesis Inhibitors on Blood Vessels.- Antiangiogenic Therapy for Normalization of Tumor Vasculature and Microenvironment.- Metronomic Antiangiogenic Chemotherapy: Questions and Answers.- Anti-Angiogenic Tumor Therapy in Clinical Studies.- The Development of Avastin.- Clinical Development of Sorafenib (BAY 43–9006) VEGFR and RAF Inhibitor.- Clinical Development of the VEGFR Signalling Inhibitor AZD2171.- Clinical Development of Sunitinib Malate.- The EGF(R) and VEGF(R) Pathways as Combined Targets for Anti-Angiogenesis Trials in Cancer Therapy.- Imaging the Effect of Anti-Angiogenic Tumor Therapy in Clinical Studies.- Vandetanib (ZACTIMA™; ZD6474): Preclinical and Clinical Development.- Integrins: Targets for Anti-Angiogenic Therapy.- Thalidomide in Multiple Myeloma.- Surrogate Markers of Angiogenesis.- Vascular Disrupting Agents in Cancer Therapy.