Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and patho...
Зміст
Introduction into lipoxygenases.- 5-Lipoxygenase.- Leukotriene A4 hydrolase and LTC4 synthase.- Catalytic multiplicity of 15-lipoxygenase-1 orthologs (ALOX15) of diffe...
Про автора
Prof. Dr. Dieter Steinhilber, born 1959, studied pharmacy at the University of Tübingen. After an assistantship there he spent a postdoc period with Prof. Bengt Samuelsso...