This book illustrates recent advances in developing sensitive and selective electrochemical biosensors for their whole blood application. Known to be a cutting-edge and fast-growing technology, electrochemical biosensors demonstrate their potential in laboratories, industries, and healthcare to achieve specific and direct target detection in complex media, and have become an emerging technology for guiding personalized medicine. The book first demonstrates methods and models to cover the detection of a variety of target molecules in whole blood, including ions, small molecules, nucleic acids, proteins, cells, etc. Then, it provides comments on various detection strategies employed to improve sensors’ sensitivity, specificity, selectivity, and reproducibility as well as presenting the laws and principles. In addition, it summarizes achievements and challenges from recent years. Finally, it provides future perspectives and opportunities in electrochemical biosensors including pointof care detection, molecular diagnostics and the integration of this sensor platform with multidisciplinary technologies, towards the ultimate goal of personalized medicine. The book integrates abundant viewpoints from multiple sciences and is helpful and valuable to a wide readership in the various fields of biochemistry, biophysics, bioengineering, and pharmaceutics.
Зміст
Introduction.- Electrochemical biosensors and the signaling.- Electrochemical biosensors for ions detection.- Electrochemical biosensors for neurotransmitters detection.- Electrochemical biosensors for metabolites detection.- Electrochemical biosensors for drugs detection.- Electrochemical biosensors for amino acids detection.- Electrochemical biosensors for nucleic acids detection.- Electrochemical biosensors for micro RNA detection.- Electrochemical biosensors for hepatic and cardiac biomarkers detection.- Electrochemical biosensors for inflammatory biomarkers detection.- Electrochemical biosensors for tumor biomarkers detection.- Electrochemical biosensors for cells and cell exosomes detection.- Future perspectives of electrochemical biosensors for whole blood analysis.
Про автора
Fan Xia is a full professor at China University of Geosciences. His research interests and strength focus on the frontier fields of bioanalytical chemistry, particularly with a significant achievement in the field of nanochannels and nanopores for the application of trace biomolecules analysis in complex matrix. His scientific interest is focused on Bio-Analytical Chemistry. He has published more than 150 papers, which were cited by over 8000 times, H-factor is 50.
Hui Li is a full professor at China University of Geosciences. She received her Ph D degree from University of Bern as a Marie-Curie fellow and pursued her research as a postdoc fellow at University of California, Santa Barbara, with the support of “Early postdoc mobility” fellowship from Swiss National Science Foundation. Her research focuses on the development of biosensors for the diagnostics of disease and health monitoring.
Shaoguang Li is a full professor at China University of Geosciences. He received his Ph D from Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences and was a postdoc fellow at University of Bern and University of California, Santa Barbara. His research interests are the development of functional nucleic acids for bioimaging and biosensor applications.
Xiaoding Lou is a full professor at China University of Geosciences since 2017. She received her Ph D degree from Wuhan University and then worked as a research associate at the Hong Kong University of Science and Technology. In 2016, she conducted her work at University of California, Santa Barbara as a visiting scholar. Her research focuses on the design of peptide- or DNA-modified probes and their applications in precise cellular analysis.
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