The potential lipotoxic effect of accumulation of fatty acids in
non-adipose tissues is thought to be a major component in the
development of insulin resistance. Chronic exposure to high
concentrations of free fatty acids in the blood affects pancreatic
beta cell function, insulin secretion and lipid synthesis in the
liver, and storage in adipose tissue. Maintaining the normal levels
of fatty acids requires coordinated regulation between the liver,
adipose tissue and skeletal muscle.
This book deals with the molecular aspects of fatty acid action
in obesity and insulin resistance. The topics include lipid
metabolism and adipose tissue biology, and beta cell function and
insulin resistance. Chapters deal with the molecular genetics and
molecular physiology of energy homeostasis.
Зміст
Symposium on Fatty acids and lipotoxicity in obesity and diabetes,
held at Tsinghua University, Beijing, China, 17-19 October
2006.
Editors: Gregory Bock (Organizer) and Jamie Goode.
This symposium is based on a proposal made by Peng Li.
Bruce M. Spiegelman – Chair’s introduction.
Bruce M. Spiegelman – Transcriptional control of energy
homeostasis through the PGC1 coactivators.
Discussion.
Stephen O’Rahilly – Human obesity and insulin
resistance: lessons from experiments of nature.
Discussion.
Deborah M. Muoio and Timothy R. Koves – Lipid-induced
metabolic dysfunction in skeletal muscle.
Discussion.
Alan D. Attie, Matthew T. Flowers, Jessica B. Flowers, Albert K.
Groen, Folkert Kuipers and James M. Ntambi – Stearoyl-Co A
desaturase deficiency, hypercholesterolaemia, cholestasis and
diabetes.
Discussion.
Karen Reue – The role of lipin 1 in adipogenesis and lipid
metabolism. Discussion.
David Carling – The role of the AMP-activated protein kinase in
the regulation of energy homeostasis.
Discussion.
Gökhan S. Hotamisligil – Endoplasmic reticulum stress and
inflammation in obesity and type 2 diabetes.
Discussion.
Ira Tabas, Tracie Seimon, Jerry Arellano, Yankun Li, Fabien
Forcheron, Dongying Cui, Seongah Han, Chien-Ping Liang, Alan Tall
and Domenico Accili – The impact of insulin resistance on
macrophage death pathways in advanced atherosclerosis.
Discussion.
Sandra Lobo and David A. Bernlohr – Fatty acid transport in
adipocytes and the development of insulin resistance.
Discussion.
Paul N. Black and Concetta C. Di Russo – Vectorial acylation:
linking fatty acid transport and activation to metabolic
trafficking.
Discussion.
Günther Daum, Andrea Wagner, Tibor Czabany, Karlheinz
Grillitsch and Karin Athenstaedt – Lipid storage and mobilization
pathways in yeast.
Discussion.
John Zhong Li and Peng Li – Cide proteins and the development of
obesity. Discussion.
General discussion I.
Visualizing brown adipose tissue with FDG-PET.
Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, Kazuo Hara
and Kohjiro Ueki – Adiponectin and adiponectin receptors in
obesity-linked insulin resistance.
Discussion.
Gabriel Pascual, Amy L. Sullivan, Sumito Ogawa, Amir Gamliel,
Valentina Perissi, Michael G. Rosenfeld and Christopher K. Glass
-Anti-inflammatory and antidiabetic roles of PPARgamma.
Discussion.
Final discussion.
Nutrition, ageing and lipotoxicity.
Index of contributors.
Subject index.
Про автора
The Novartis Foundation is an international scientific and
educational charity, which promotes the study and general knowledge
of science and in particular encourages international co-operation
in scientific research.
Chairman: Bruce Spiegelman.
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