Heavy metals essential to organisms are termed “biometals”. Bio-inorganic chemistry deals with the functions of biometals in vivo at an atomic to molecular level, while cellular regulation of biometals such as absorption and transport has been investigated in cell biology. Although these research fields have independently developed and matured, interdisciplinary information across these fields is required for a comprehensive understanding of the roles of biometals at atomic to molecular, cellular and organism levels.
This book highlights the latest progress in zinc biology, from its chemistry to its association with diseases. Zinc is the second most abundant trace metal in living organisms, playing a crucial role in many biological processes. It functions as a catalyst in enzymatic reactions, a structural component in proteins, and a signalling molecule in cellular pathways. Zinc homeostasis is tightly regulated by proteins involved in absorption, storage, transport, and utilization. Disruptions in homeostasis are linked to various diseases.
Resulting from a 5-year project on Integrated Biometal Science in Japan, this book not only documents the latest research but also fills a gap between chemical understanding and our real life.
Зміст
- Quantitative Imaging of Labile Zinc in Intracellular Organelles Using Fluorescent Probes
- Zinc Conditional Proteomics Using Zinc-responsive Protein Labelling Reagent and Recent Examples of Expansion to Other Biometals
- Structure and Biological Activity of Zinc Complexes Coordinated with Chalcogen Atoms
- Structure Activity Relationship of Insulin-mimetic Zinc Complexes Having Hydroxyazine-type Heterocyclic Bidentate Ligands
- Regulation of Zn Absorption Process in the Small Intestine: Functional Insights into Zn Transporters ZIP4 and ZNT1
- Zinc Homeostasis Ensures Protein Homeostasis in the Early Secretory Pathway
- Regulation of Pluripotent Stem Cell Pluripotency and Differentiation Through Zinc Mobilization
- Importance of Zinc in Epigenetic Control
- Role of ZNT5-6 and ZNT7 in Zinc Enzyme Activation
- TRPC6-mediated Zn2+ Influx as a Cardiotonic Mediator
- Role of Zinc in Brain Functions, and Brain Zinc Dyshomeostasis
- Regulation of Skin Wound Healing by Zinc and Zinc Transporters
- Role of Zinc Homeostasis in the Pathophysiology of Diabetes
- Zinc Transporters and Zinc Signaling in Disease Pathogenesis
- Roles of Zinc and Zinc Transporters in Breast Cancer
- Role of Zinc in the Pathogenesis of Inflammatory Bowel Disease: From Trace Elements to Zinc Signaling
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