Mark Chang & Shein-Chung (Duke Univ, USA) Chow 
Adaptive Design Methods in Clinical Trials [PDF ebook] 

With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA”s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clini