Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood.
Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters).
This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.
Зміст
Cellular and biochemical mechanisms of obesity.- The role of inflammation in obesity.- Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity.- The role of the inflammasome in obesity.- Adipose tissue macrophages and their polarization in health and obesity.- Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation.- The interplay between adipocytes and immune system cells in the pathophysiology of obesity.- Neuropeptides in Obesity and Metabolic Disease.- Adiposity and the Role of Neuroendocrine Hormones in Energy Balance.- Obesity in menopause.- Ovarian hormones and obesity.- The role of tissue-specific glucocorticoids in central obesity.- Thyroid function in obesity.- Glucocorticoid hormones: cause or cure for obesity.- Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota.- Recent advances in leptin and obesity.- Pathophysiology of obesity due to neurohormonal dysregulation and autophagy.- The Role of the Autonomic Nervous System in the Pathophysiology of Obesity.- Disturbance of neuronal signals in the pathophysiology of obesity.- The sympathetic neuro-adipose connection and the control of body weight.- Sympathetic activation in obesity.- Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism.- Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome.- Should the sympathetic nervous system be a target to improve obesity?.- Metabolic Syndrome and Oxidative Stress: A Complex Relationship.- The role of oxidative stress in the pathogenesis of obesity.- How effective are antioxidant supplements in obesity.- Oxidative stress in obesity: a critical component in human diseases.- Cellular mechanisms involved in the pathophysiology of obesity during oxidative stress.- Oxidative stress and metabolic pathologies: from an adipocentric point of view.- Oxidative stress contributes to the pathogenesis of obesity.- The genetics of oxidative stress in obesity.- Increased oxidative stress is associated with adipocyte fat accumulation.- The vicious cycle of oxidative stress and obesity.- GPCR-Mediated Signaling of Metabolites in the pathophysiology of obesity.- Ceramide signaling in obesity.- The role of the triggering receptor in the pathophysiology of obesity.- The AMPK pathway in the development of obesity.- Interleukin-1 superfamily: Divergent roles in obesity.- Ghrelin Receptor Mutations and Human Obesity.- Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism.- JAK/STAT signaling pathway in the development of obesity.- SIRT1 and SIRT3 as mediators for the development of obesity.- Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.- Interplay between Obesity and c GMP Signaling in adipose tissue.
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