This book presents multidisciplinary research that expands our understanding of the innovation system (IS) and the entrepreneurial ecosystem (EE) perspectives on regional economic development. It critically reviews the two concepts and explores the promise and the limits of bridging IS and EE, particularly as applied outside of the bubbling global hubs or to the types of entrepreneurship different from the high-growth variety. Building on these insights, it delves deeper into the links between the academic knowledge and its practical applications in a variety of contexts – from a vibrant London suburb to Latin American countries – with the goal of offering place-specific policy implications. Additionally, the authors advance the inquiry by examining some of the overlooked dimensions of the systemic approaches to economic development such as informal and social entrepreneurship and offers a comprehensive view of the current research at the intersection of the IS and the EE frameworks from the practical perspective. Entrepreneurship and innovation – and relatively new ways to study and understand those within the systems framework – are at the forefront of scholarly and policy debate on economic growth at the moment, making this an important and timely work for academics and policy makers. Contributors include: V. Andonova, M. Belitski, J.E. Cassiolato, A.P. da Costa e Silva Lima, C. De Fuentes, G. de Oliveira Santos, M. del Carmen Roman Roig, N.A. Dentchev, A. Diaz Gonzalez, J. Federico, A. Godley, M. Gonzalo, A. Guerrero Alvarado, S. Ibarra Garcia, H. Kantis, R. Lebre La Rovere, M.C.J. Lustosa, H.M. Martins Lastres, F. Modrego, J.A. Peerally, J. A. Perez-Lopez, M.G. Pessoa de Matos, M.G. Pezzi, R. Pugh, M.G.v. B. Podcameni, J. Schmutzler, V. Servantie, A. Tsvetkova, J.M. Zabala-Iturriagagoitia