This text has been written as a practical guide, based on the author’s experience over the last 40 years of daily clinical practice and aiming to place the modern approach to the management of infertility in the context of sound theory and evidence-based therapy. It provides the reader with a comprehensive classification of the causes of infertility, their investigation, and their management. This new edition covers many advances in the understanding and management of infertility and other updates to practice–for example, a greater understanding of the pathophysiology of ovarian aging and ovarian reserve testing; the classification of disorders of ovulation and management of polycystic ovary syndrome; the refinement of regimens for superovulation, improved embryo culture systems, and the use of artificial intelligence for the selection of embryos; assessments for endometrial receptivity and management of recurrent implantation failure; pre-implantation genetic testing (PGT) as a therapeutic tool opening up the possibility for aneuploidy screening; as well as the latest thoughts on nutritional health, periconception care, and the exciting new world of the microbiome.