The Gn RH Neuron and its Control examines the developmental biology of Gn RH neurons including their birth in the nasal placode of the early embryo, perinatal programming, and sexual differentiation, in addition to the hypothalamic mechanisms that control Gn RH neurons in adulthood to generate pulsatile and surge modes of Gn RH secretion throughout the major life stages including aging. The morphology, electrophysiology, signal transduction pathways, transcriptional regulators, and genomics underlying function of the adult Gn RH neuron is discussed in detail, as is the neuroendocrinology and cell biology governing the generation of both modes of Gn RH release.
The book also reviews the neurobiological mechanisms and circuitry responsible for the modulation of the activity of Gn RH neurons by season, stress, nutrition, and metabolism, and covers the current and potential therapeutic approaches to regulating Gn RH secretion and action. Filled with newly identified research and classical fundamental knowledge to Gn RH biology, it will provide students, researchers, and practitioners with an in-depth understanding of reproductive neuroendocrinology.
This is the fifth volume in the Masterclass in Neuroendocrinology Series, a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
Mục lục
List of Contributors vii
Series Preface xi
Preface xiii
About the Companion Website xv
Part I Historical Introduction to the Gn RH Neuron
1 The Framework Upon Which Current Research on the Gn RH Neuron and its Control is Built 3
Tony M. Plantand Allan E. Herbison
Part II Gn RH Neuron Development
2 Prenatal Development of Gn RH Neurons 15
Yufei Shanand Susan Wray
3 Fetal/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin–Gn RH Neuronal Network 43
Hiroko Tsukamura, Kei‐ichiro Maedaand Yoshihisa Uenoyama
4 Postnatal Development of Gn RH Neuronal Function 61
Ei Terasawa
Part III Gn RH Neuron Biology
5 Regulation of Gn RH Gene Expression 95
Hanne M. Hoffmannand Pamela L. Mellon
6 Morphology of the Adult Gn RH Neuron 121
Rebecca E. Campbell
7 The Anatomy of the Gn RH Neuron Network in the Human 149
Katalin Skrapitsand Erik Hrabovszky
8 Electrophysiology of Rodent Gn RH Neurons 177
Richard Pietand Allan E. Herbison
9 Anatomy and Physiology of Gn RH Neurons and Their Control of Pituitary Function in Fish 203
Yoshitaka Oka
Part IV Regulation of Gn RH Neuron Function
10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of Gn RH Neuronal Function 227
Vincent Prevotand Ariane Sharif
11 Genetic Strategies Examining Kisspeptin Regulation of Gn RH Neurons 259
Michael Candlish, Philipp Wartenbergand Ulrich Boehm
12 KNDy Hypothesis for Generation of Gn RH Pulses: Evidence from Sheep and Goats 289
Robert L. Goodman, Satoshi Okhura, Hiroaki Okamura, Lique M. Coolenand Michael N. Lehman
13 Generation of the Gn RH Surge and LH Surge by the Positive Feedback Effect of Estrogen 325
Iain Clarke
14 Influence of Stress on the Gn RH Neuronal Network 357
Pasha Grachevand Kevin T. O’Byrne
15 Metabolic Regulation of Gn RH Neurons 383
Maggie C. Evansand Greg M. Anderson
16 Seasonal Control of the Gn RH Neuronal Network as a Means of Uncovering Novel Central Mechanisms Governing Mammalian Reproduction 411
Sébastien Milesi, Paul Klosenand Valerie Simonneaux
Part V Gn RH in the Clinic
17 Human Genetics of Gn RH Neuron Function 445
A. Kemal Topalogluand L. Damla Kotan
18 Modulators of Gn RH Secretion and Therapeutic Applications 469
Claire L. Newton, Ross C. Andersonand Robert P. Millar
Index 499
Giới thiệu về tác giả
Editors:Allan E. Herbison, University of Otago, New Zealand.
Tony M. Plant, University of Pittsburgh, USA.
Thêm sách điện tử từ cùng một tác giả / Biên tập viên
950 Ebooks trong thể loại này
