With the increase in volume, velocity and variety of information, researchers can find it difficult to keep up to date with the literature in their field. This invaluable volume contains analysed, evaluated and distilled information on the latest in carbohydrate research. The discovery and synthesis of novel carbohydrates and mimetics with diverse applications continues to be a major challenge for carbohydrate chemists. The understanding of the structure and function of carbohydrates and glycoconjugates remains vital in medicine and molecular biology.
This volume collates modern carbohydrate research from theory to application and demonstrates the importance of carbohydrates in new lead generation. It is of benefit to any researcher who wishes to learn about the latest developments in the carbohydrate field.
Mục lục
Contemporary glycoconjugation chemistry; Advances in applications of NMR methods to uncover the conformation and recognition features of glycans; Recent advances in Kdo-glycoside synthesis; Predictable and highly efficient preparation of carbohydrate-based vaccines: Squaric acid chemistry is the way to go; Synthetic Approaches to Cyclodextrins and Their Analogues; Bacterial lipopolysaccharides covalently bound to hopanoids: key molecules that favour the life of Bradyrhizobia in stressful environments; Giant ds DNA viruses taste for sugars; Glycosteroids: a specific type of glycolipids with self assembly properties; Recent examples of novel synthetic approaches to diverse amino-sugars; Fim H Antagonists – Solubility vs. Oral Availability; Ferrier rearrangement. An update on recent developments; Recent advances in the synthesis of iminosugars. An insight into the cascade addition of Grignard reagents to halonitriles/cyclization;
Giới thiệu về tác giả
Dr Yves Queneau, Research Director at CNRS, is Head of the Organic and Bioorganic Chemistry Laboratory at INSA Lyon, Deputy-Director of the “Institut de Chimie et Biochimie Moléculaires et Supramoléculaires” (ICBMS), University of Lyon, France and Honorary Professor at the University of Hull, UK. After his doctorate on aqueous Diels-Alder reactions involving glycodienes under the supervision of Professor André Lubineau (Orsay, 1988) he was appointed as CNRS fellow and worked on cycloaddition reactions towards complex sugars. He then spent one year in 1992 in Professor Samuel J. Danishefsky’s group in Memorial Sloan Kettering Cancer Center in New York, USA. He later moved to Lyon in a mixed CNRS-industrial research facility dedicated to sucrose chemistry (1995-2003) before joining its present position where he develops his research in organic and biological chemistry with a particular interest for the use of carbohydrates as renewable raw materials.
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