This comprehensive and stimulating Handbook examines the contribution of political economy to public policy. It provides an overview of several strands of critical political economy, supported by case studies from OECD countries, Latin America, South Africa, and South and East Asia.With discussions on key theories of political economy, the Handbook introduces cultural and feminist political economies, engaging critically with ordoliberalism and New Public Management. Chapters feature discussions on political economic approaches to the global division of labor, financialization and dispossession in Latin America, ecological perspectives on sustainability in China, global exploitation chains in agriculture, and postcolonial criticisms of economic development. The Handbook concludes with an exploration of the relationship between political economy and social policy, global health, and public policies.Providing a combination of critical engagement with the various theories of political economy and their application to key economic policies, this will be essential reading for students and academics in comparative politics, economics and finance, international relations, political economy, public policy, and political science. Policymakers interested in addressing socially and environmentally unsustainable practices will also find this an illuminating and informative resource.