This book comprehensively reviews current and novel treatment strategies against human parasites, including protozoans and helminths, using natural products. The initial chapters summarize the conventional treatment strategies and natural-product based therapeutics against these parasites. It discusses biochemical tools and techniques for the discovery of natural product based drugs against human parasites. The book also covers the ingenious and innovative mechanisms to achieve drug resistance by the protozoan parasites and strategies to overcome the resistance. It entails mechanistic insight into the modulation of host immune responses to delay or inhibit parasite clearance and explores host-pathogen interactions that mediate immunity against subsequent parasite challenge. In turn, the volume helps in understanding the immunobiology of the parasites and tools to identify candidate vaccine antigens and novel delivery systems against the protozoan parasites. Lastly, it explores the role of advanced methods, including nanotechnology, marine bioprospecting, and microorganisms-derived biochemicals against the protozoan parasites.
This book is useful for students and researchers of pharmacology, parasitology, zoology and other allied fields.
Mục lục
Chapter 1. Recent advances on the discovery of plants derived bioactive scaffolds/extracts against parasitic diseases.- Chapter 2. Applications of Computational Methods in Natural Products based Drug Discovery.- Chapter 3. Natural Product-Based Drug Designing for treatment of Human parasitic diseases.- Chapter 4. Secondary Metabolites of Plant Origin in Parasitic manifestations.- Chapter 5. Exploring marine biodiversity as alternative resources for treatment of Human Parasitic Diseases.- Chapter 6. Marine Bioprospecting for the Treatment of Human Parasitic Diseases.- Chapter 7. Microorganisms-Derived Biochemicals: Potential Drugs for Human Parasitic Diseases.- Chapter 8. Plant-Based Vaccines against Human Parasitic Diseases.- Chapter 9. Nanotechnology: its usages in drug delivery for the treatment of Human Parasitic Diseases.- Chapter 10. Therapeutic Potential Of Benzopyrones Against Antiparasitic Diseases.- Chapter 11. Antimicrobial peptides (AMPs): current state and future prospectsfor the treatment of human parasitic diseases.- Chapter 12. Pathway To Register Natural Product-Derived Therapeutics.- Chapter 13. Recent Advances in the Treatment of Parasitic Diseases: Current Status and Future.- Chapter 14. Strategies and challenges for developing plant-based therapeutics against Protozoans.- Chapter 15. Recent approaches to combat toxoplasma gondii with plant-derived alternatives.- Chapter 16. Target-based rational improvement strategies and pitfalls in Leishmania drug discovery.- Chapter 17. Versatile Structurally Diverse Natural Products and Their Semisynthetic Analogs as Potential Anti-leishmanial Drugs.- Chapter 18. Promising compounds of plant origin and their synthetic analogs against Trypanosomes.- Chapter 19. Pathogenesis and Immune Response in T. cruzi infection: Quest for Natural compound-based drugs.- Chapter 20. Limitations of current drugs and prospects of plant-based compounds and their constructed analogues as therapeutics for treatment of malaria.- Chapter 21. An Analytical Approach to Progression in Malaria Therapeutics.- Chapter 22. Malaria Drug Discovery: How to tackle the problem of Drug Resistance.- Chapter 23. Approaches to drug discovery against Ascariasis: Opportunity and challenges in plant-based products.- Chapter 24. The Potential of Plant Secondary Metabolites as Drugs or Leads Against Helminths.- Chapter 25. Drug Resistance in Helminth parasites: Role of plant based natural therapeutics.- Chapter 26. Schistosomiasis: current and future strategies to develop novel therapeutics.
Giới thiệu về tác giả
Dr. Archana Singh
Dr. Archana Singh, Assistant Professor, Hansraj College, University of Delhi, is a Ph. D. from National Institute of Plant Genome Research, Arunaasaf, Ali Marg, New Delhi. Dr. Singh is a recipient of “Young Scientist fellowship” (2012) and “Early Career Research Award” (2017) from SERB, DST, Government of India; Raman Post-Doctoral fellowship from University Grant Commission and European Molecular Biology Organization fellowship from Heidelberg, Germany. Dr. Archana has worked as a visiting scientist at Max Planck Institute of Chemical Ecology, Jena, Germany during 2019-20 and at University of Kentucky, Lexington, USA (2016-17). Dr. Archana has been bestowed with Best Researcher Award, 2017 and Best Teacher Award, 2018. Dr. Singh has published many research articles in Journals of National and International repute such as International Journal of Biological Macromolecules, BBA Molecular Basisof Disease, Clinica Chimica Acta, Scientific Reports, Computational Biology and Chemistry, Bioorganic & Medicinal Chemistry, Anti-Cancer Agents in Medicinal Chemistry etc. Dr. Singh has also filed a patent on diagnosis of Mycobacterium tuberculosis. Dr. Archana has also edited two books and authored many book chapters published by Springer and Elsevier. Dr. Archana is a life-member/member of IBS, and AIMI. Besides, she has served as a reviewer for several international and national journals and book proposals. Dr. Singh has trained many post-graduate and graduate students, and currently supervises two doctoral and one post-doctoral researchers. Currently, she is working on “Plant Immunity and Human Health” with special emphasis on drug discovery for cancer, tuberculosis, parasitic diseases of human and allergens of plant origin.
Dr. Brijesh Rathi obtained Ph.D. degree in Chemistry from University of Delhi and currently, working as Assistant Professor of Chemistry at Hansraj College University Enclave, University of Delhi, India. He is recipient of the prestigious “young scientist fellowship” (2010), “early career research award” (2016) from DST, Government of India, CAPES-Print Fellowship (2019) from Ministry of Education Brazil, and the prestigious “Excellence Awards for In Service Teachers” (2018) by University of Delhi. Dr. Rathi has been Visiting Assistant Professor (2016–2017) at Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, USA, and now Affiliate Faculty at University of Loyola Chicago and University of Debrecen, Hungary. He has published more than 60 papers in various journals of National and International repute. Dr. Rathi holds the position of section editor for Current Topics in Medicinal Chemistry, and associate editor membership of Chemical Biology Letters. Dr. Rathi has supervised five undergraduate research students in the past, and currently supervising various doctoral students and one master thesis. His main research interests are centered at the development of new antiparasitic and antiviral agents and their target identification.
Dr. Anita Kamra Verma, is Professor of Zoology has over 32 years of teaching and research experience at Kirori Mal College, University of Delhi, Delhi, India. She has done Post -Doctoral research at National Institute of Immunology, New Delhi. (1994-1998), and worked as a Senior Scientist at the School of Pharmacy, University of Manchester (1998-2000). Her research interests include identifying predictive biomarkers and using plant products as immunomodulators to mitigate cancer, arthritis and osteoporosis, exploiting nanotherapeutics for human health and disease, making in-vivo models for quantifying nanoparticlulate drug delivery for cancer, diabetes and arthritis, developing rationale designs based on whole body and cellular pharmacokinetics-pharmaco-dynamic profile of drugs. She has two Patents on Anti-Cancer Drugs and over 125 publications in peer reviewed international journals of repute and 12 book chapters to her credit. She has been conferred with various prestigious awards notably the Distinguished Collaborator Award, 2019, from UClan, UK, Best Researcher Award, 2018 and Best Teacher Award, 2017, Best paper award from ‘Rapid Prototyping Journal’ in 2016 and Charles Darwin Gold medal in 2009. Dr Verma is a member of many National and International scientific societies and organizations importantly, AAPS Pharm Sci Tech, Nanotechnology, BMC Complementary and Alternative Medicine, Pharmaceutical Research, International Journal of Pharmaceutics; Bioscience Reports, International Research Journal of Biotechnology, Nanoscience & Nanotechnology in Biology and Medicine, Journal of Biomaterials and Nanobiotechnology. Dr. Verma has been a member of the selection committee for the prestigious Khorana Scholar program partnered by Department of Biotechnology (DBT), Govt. of India, Indo-U.S. Science and Technology Forum (IUSSTF) and WINStep Forward for 4 years. Dr. Verma has supervised 14 Ph D students and is currently supervising six doctoral and two post-doctoral students.
Dr. Indrakant K. Singh received his Ph.D. in Zoology from the Department of Zoology, University of Delhi (DU). Dr. Singh is currently working as Professor (Zoology), Deshbandhu College, & Fellow, Delhi School of Public Health, Institute of Eminence, University of Delhi, New Delhi, where he enjoys teaching, Immunology, Genomics, Computation Biology, and Medical Diagnostics. He is a recipient of the Young Scientist Award/Fellowship (2013-2016) by Science & Engineering Research Board (SERB), Raman-Post Doctoral Fellowship (2016-17), Max-Planck Society Visiting Post-Doctoral Fellowship (2019) and ICMR-DHR Long Term International Fellowship for Young Bio-medical Scientists (2019-20 & 2022-23), Prestigious Delhi University Excellence Award for Teacher in Service 2021 and DHR Long Term Fellowship for Training in Indian Institute (2022). He has also been awarded with Best Researcher, 2017 and Best Teacher, 2018 by Grace India Trust India. Dr. Singh also filed two (2) patents (India & USA) on Mycobacterium tuberculosis. Prof. Singh is a life-member/Fellow/member of many prestigious academic societies including the RSB, AMCA, IBS, and AIMI, ESI, BSI. Dr. Singh has published more than 50 quality research articles in peer-reviewed journals of international repute like Scientific Reports, International Journal of Biological Macromolecules, Critical Reviews in Biotechnology, Clinica Chimica Acta, International Journal of Molecular Sciences and BBA Molecular Basis of Disease, Computational Biology and Chemistry, Phytochemistry, Anti-Cancer Agents in Medicinal Chemistry. He is an editorial board member in many international and national journals like Scientific Reports-Springer Nature etc. He has also edited four books and authored more than 30 book chapters published by Springer, Taylor & Francis and Elsevier. Dr. Singh has served as a reviewer for several international and national refereed journals. Dr. Singh has trained many post-doctoral, doctoral, post-graduate and graduate students, and currently supervises five doctoral and two post-doctoral, fore M.Tech. students. Over the years, he has pursued his research interests in the areas of Molecular biology, Cancer Biology, and Functional Genomics.
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