This unique book describes newly discovered proteolytic enzymes and their biological function. In many cases, these enzymes are targets for new drug discovery in order to provide new therapeutic approaches to control human diseases and/or metabolic conditions. The chapters in this book will help other investigators to pursue drug discovery by detailing methods of production and assay of the enzymes. In addition, the latest structural studies that are described in the book will permit rapid advances in drug design. The most important elements of this book are the state-of-the-art, detailed descriptions of the properties of the proteolytic enzymes. The chapters in the book, written by leading experts in the field, collect the best work on the topics with complete bibliographies for each target enzyme. The illustrations are highly informative to aid and facilitate a new design of inhibitors that can be developed as drug candidates. Key chapters include those by Mark Gorrell and Catherine Abbott, both describing dipeptidyl peptidases, which have been implicated in a number of metabolic conditions including diabetes. The chapters are written from two very different perspectives, thus enriching the literature in this area. In addition, the chapter by Sheena Mc Gowan focuses on aminopeptidases from the malaria parasite, Plasmodium falciparum, and the chapter by Ben Dunn deals with the aspartic peptidases from the same organism.
Mục lục
Dipeptidyl peptidases: Substrates and therapeutic targeting in human health and disease;
The Metalloproteases Meprin ? and ?: Pathophysiological roles in Inflammation, Cardiovascular Disease, Cancer, and Fibrosis;
Glutamate Carboxypeptidase II as a Therapeutic Target;
The Role of Proteolytically Inactive Serine Proteases from Sarcoptes scabiei in Complement Evasion;
Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy;
Discovery of the Cysteine Protease Cathepsin B as a Drug Target for Alzheimer’s Disease;
Plasmodium falciparum Neutral Aminopeptidases: Development of novel anti-malarials by understanding enzyme structure;
Blood-feeding human hookworm proteases;
Structural Mechanisms of Inactivation in Proteolytically Inactive Serine Proteases from Sarcoptes scabiei;
The Aspartic Proteinases from the Malaria Parasite: Structure and Function of the Plasmepsins
Giới thiệu về tác giả
Ben M Dunn is a Distinguished Professor of Biochemistry & Molecular Biology at the Department of Biochemistry & Molecular Biology, University of Florida, USA. He is also an NIH-funded Investigator and is currently supported by a MERIT award for the NIAID. He was President of the International Proteolysis Society from 2003-2005 and is currently President of the American Peptide Society.
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