Board on Environmental Studies and Toxicology & Board on Life Sciences 
Application of Toxicogenomics to Cross-Species Extrapolation [PDF ebook] 
A Report of a Workshop

Ủng hộ

Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists’ ability to make connections between data from experimental animal studies and human health.

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Ngôn ngữ Anh ● định dạng PDF ● Trang 58 ● ISBN 9780309656139 ● Nhà xuất bản National Academies Press ● Được phát hành 2006 ● Có thể tải xuống 3 lần ● Tiền tệ EUR ● TÔI 7147946 ● Sao chép bảo vệ Adobe DRM
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