Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia.
This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits.
The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.
Mục lục
Biochemical Diversity of 2-Oxoglutarate Dependent Oxygenases; Introduction to Structural Studies on 2-Oxoglutarate Dependent Oxygenases and Related Enzymes; Mechanisms of 2-Oxoglutarate-Dependent Oxygenases; Synthetic Models of 2-Oxoglutarate-Dependent Oxygenases; Collagen Hydroxylases; The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensing; Jmj C Lysine Demethylases; Alk B and its Homologues—DNA Repair and Beyond; RNA Demethylation by FTO and ALKBH5; Role of ALKBH8 in the Synthesis of Wobble Uridine Modifications in t RNA; The TET/JBP Family of Nucleic Acid Base-Modifying 2-Oxoglutarate and Iron-Dependent Dioxygenases; 2-Oxoglutarate-Dependent Hydroxylases Involved in DNA Base J (β-D-glucopyranosyloxymethyluracil) Synthesis; Dioxygenases of Carnitine Biosynthesis: 6-N-Trimethyllysine and γ-Butyrobetaine Hydroxylases; Phytanoyl-Co A Hydroxylase: a 2-Oxoglutarate Dependent Dioxygenase Crucial for Fatty Acid Alpha-Oxidation in Humans; Role of 2-Oxoglutarate Dependent Oxygenases in Flavonoid Metabolism; Gibberellin Metabolism; 2-Oxoglutarate Dependent Oxygenases of Cephalosporin Synthesis; Recent Advances in the Structural and Mechanistic Biology of Non-Heme Fe(II), 2-Oxoglutarate, and O2 Dependent Halogenases; Isopenicillin N Synthase; 1-Aminocyclopropane-1-Carboxylic Acid Oxidase; 4-Hydroxyphenylpyruvate Dioxygenase and Hydroxymandelate Synthase: 2-Oxo Acid-Dependent Oxygenases of Importance to Agriculture and Medicine
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