Accelerated partial breast irradiation (APBI) is being rapidly introduced into the clinical management of early breast cancer. APBI, in fact, encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation. This text is a concise handbook designed to assist the clinician in the implementation of APBI. This includes a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications.
Mục lục
Accelerated Partial Breast Irradiation: History, Rationale, and Controversies.- Who Is a Candidate for APBI?.- Pathologic Anatomy of Early-Stage Breast Cancer and Its Relevance to APBI: Defining the Target.- The Radiobiology of Accelerated Partial Breast Irradiation.- Surgical Considerations in Partial Breast Irradiation.- Physics of Accelerated Partial Breast Irradiation.- Quality Assurance for Accelerated Partial Breast Irradiation.- Overview of North American Trials.- An Overview of European Clinical Trials of APBI.- The Phase III Trials: Obtaining Definitive Answers.- The Virginia Commonwealth University Technique of Interstitial Brachytherapy.- Accelerated Partial Breast Irradiation: The William Beaumont Hospital Technique of Interstitial Brachytherapy.- Brachytherapy Techniques: The Arizona Approach.- The Mammo Site Technique for Accelerated Partial Breast Irradiation.- Permanent Breast Seed Implants.- 3D Conformal External-Beam Technique.- External-Beam Partial Breast Irradiation: The New York University Prone Technique.- APBI 3D Conformal External Beam: The MGH Technique.- APBI with 50 k V Photons: Targeted Intraoperative Radiotherapy (TARGIT).- APBI Intraoperative Technique with Electrons.- Intraoperative Radiation Therapy During Breast-Conserving Surgery; the Memorial Sloan—Kettering Cancer Center Technique.- Normal Tissue Toxicity After Accelerated Partial Breast Irradiation.- Emerging Technologies Part I: New Brachytherapy Catheter Systems.- Emerging Technologies Part II: Novel Sources and Delivery Systems.
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