Dengue virus is a member of the Flaviviridae family, which includes
viruses associated with human diseases such as yellow fever,
Japanese encephalitis and hepatitis C. Dengue fever is
transmitted by mosquitoes, principally Aedes aegypti. There
are four serotypes of dengue virus, of which DENV-2 has been the
most prevalent in many recent epidemics. Following primary
infection, lifelong immunity develops, preventing repeated assault
by the same serotype. However, the non-neutralizing antibodies from
a previous infection or maternally acquired antibodies are thought
to form complexes with a different serotype during a subsequent
infection and cause dengue haemorrhagic fever/dengue shock
syndrome, which can be fatal. There is no treatment or vaccine
available today that can combat this emerging and uncontrolled
disease.
This book features contributions from the world’s leading
researchers working on dengue and related flaviviruses who examine
the current state of the art in the molecular biology of the dengue
virus. Particular emphasis is placed on the structure and function
of the virus and the targeting of virus proteins by potential
antiviral agents. The pathogenesis of dengue and dengue
haemorrhagic fever are discussed in detail, especially the target
cells and the specific receptors on these cells, thereby developing
a clear overview of host and viral factors that contribute to
dengue haemorrhagic fever. Finally, the book reviews the
therapeutic options, paying particular attention to ways in which
vector, host and environment can play a critical role in the spread
of this disease.
With dengue fever and other emerging viral diseases becoming
increasingly prevalent around the world, this book provides
valuable insight into the virus that causes this disease and
potential ways to manage it. It is essential reading
for all those working in tropical diseases, public health and
virology.
Praise from the reviews:
‘The book provides an excellent summary of dengue/flavivirus
research and is important for individuals and institutions
interested in emerging infectious diseases.’ MICROBIOLOGY
TODAY
Mục lục
Chair’s introduction (Charles Rice).
Dengue/dengue hemorrhagic fever: history and current status
(Duane J. Gubler).
Discussion.
Molecular biology of flaviviruses (Eva Harris, Katherine L.
Holden, Dianna Edgil, Charlotta Polacek and Karen Clyde).
Discussion.
Development of novel antivirals against flaviviruses (Chinmay G.
Patkar and Richard J. Kuhn).
Discussion.
Entry functions and antigenic structure of flavivirus envelope
proteins Karin Stiasny, Stefan Kiermayr and Franz X. Heinz).
Discussion.
General discussion I.
Multiple enzyme activities of flavivirus proteins (R.
Padmanabhan, N. Mueller, E. Reichert, C. Yon, T. Teramoto, Y. Kono,
R. Takhampunya, S. Ubol, N. Pattabiraman, B. Falgout, V. K. Ganesh
and K. Murthy).
Discussion.
Towards the design of flavivirus helicase/NTPase inhibitors:
crystallographic and mutagenesis studies of the dengue virus NS3
helicase catalytic domain (Ting Xu, Aruna Sampath, Alex Chao,
Daying Wen, Max Nanao, Dahai Luo, Patrick Chene, Subhash G.
Vasudevan and Julien Lescar).
Discussion.
Finding new medicines for flaviviral targets (Thomas H. Keller,
Yen Liang Chen, John E. Knox, Siew Pheng Lim, Ngai Ling Ma, Sejal
J. Patel, Aruna Sampath, Qing Yin Wang, Zheng Yin and Subhash G.
Vasudevan).
Discussion.
Structural and functional analysis of dengue virus RNA (Diego
Alvarez, Maria F. Lodeiro, Claudia Filomatori, Silvana Fucito, Juan
Mondotte and Andrea Gamarnik).
Discussion.
Organization of flaviviral replicase proteins in virus induced
membranes: a role for NS1′ in Japanese encephalitis virus RNA
synthesis (Vijaya Satchidanandam, Pradeep Devappa Uchil and Priti
Kumar).
Discussion.
CRM1 dependent nuclear export of dengue virus type-2 NS5
(Melinda J. Pryor, Stephen M. Rawlinson, Peter J. Wright and David
A. Jans).
Discussion.
T cell responses and dengue haemorrhagic fever (Gavin Screaton
and Juthathip Mongkolsapaya).
Discussion.
The evolutionary biology of dengue virus (Edward C. Holmes).
Discussion.
Developing vaccines against flavivirus diseases: past success,
present hopes and future challenges (John R. Stephenson).
Discussion.
A genomics approach to understanding host response during dengue
infection (Martin L. Hibberd, Ling Ling, Thomas Tolfvenstam, Wayne
Mitchell, Chris Wong, Vladimir A. Kuznetsov, Joshy George, Swee-Hoe
Ong, Yijun Ruan, Chia L Wei, Feng Gu, Joshua Fink, Andy Yip, Wei
Liu, Mark Schreiber and Subhash G. Vasudevan).
Discussion.
Mouse and hamsters models rodent models for the study of therapy
against flavivirus infections (Nathalie Charlier, Pieter Leyssen,
Erik De Clercq and Johan Neyts).
Discussion.
Secretion of flaviviral non-structural protein NS1: from
diagnosis to pathogenesis (S. Alcon-Le Poder, P. Sivard, M.-T.
Drouet, A. Talarmin, C. Rice and M. Flamand).
Discussion.
Final discussion.
Index of contributors.
Subject index.
Giới thiệu về tác giả
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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