This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. Co Q10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of Co Q10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging.
The book is organized in four sections. The first offers an overview of the function of Co Q10, highlighting the two main functions of Co Q10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants.
The second section covers research on Coenzyme 10. Topics include studiesinvolving invertebrate models, mammal studies and the influence of Co Q on longevity. Also covered is research involving the role of Co Q in senescence-accelerated mice.
Section three examines the effects of reduced Co Q in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction.
The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of Co Q10 levels by induction of synthesis or by supplementation.
Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
Mục lục
Preface.- Part 1 Basics on coenzyme Q.- Introduction. The current coenzyme Q science and knowledge.- Molecular structure, biosynthesis, and distribution of coenzyme Q.- Coenzyme Q function in mitochondria.- Extramitochondrial coenzyme Q10 in aging.- Regulation of the synthesis of Coenzyme Q10.- Part 2 Coenzyme Q in aging studies.- Coenzyme Q and aging in C. elegans.- Coenzyme Q and aging in the fruit fly Drosophila melanogaster.- The aging process and coenzyme Q: clk-1 mouse models.- Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions.- Part 3 Age-related diseases and coenzyme Q.- Coenzyme Q, mt DNA and mitochondrial dysfunction during aging.- Coenzyme Q10 and metabolic syndrome.- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases.- Immunosenescence and Co Q10.- Coenzyme Q10 in fertility and reproduction.- Part 4 Prolongevity effectors and Coenzyme Q.- Calorie restriction, longevity and coenzyme Q.- Age dependent changes of coenzyme Q levels and its induction in experimental systems.- Effects of coenzyme Q10 supplementation on elderly people.- Index.
Giới thiệu về tác giả
Guillermo López Lluch Graduated in Biology at the University of Córdoba, Spain in July, 1992. Ph D (Biology) at the University of Cordoba in July, 1997.Professor at the Pablo de Olavide, Seville, from 1998 starting as Assistant professor and obtaining a position as Lecturer/Reader in May 2003.Between June, 1999 and October, 2000 postdoctoral student granted with a Marie Curie Fellowship from the European Commission at the Department of Molecular Medicine (Rayne Institute), University College of London working on the biology of neutrophils under the supervision of Dr. Anthony W. Segal and Dr. Lodewijk V. Dekker.From October, 2018, Full Professor in the Area of Cell Biology of the Department of Physiology, Anatomy and Cell Biology of this University. Further, Associate Researcher at the Andalusian Centre for Developmental Biology (CSIC-UPO-JA) at the same University.Current research field: metabolic and antioxidant regulation during aging. The importance ofmetabolism and mitochondrial physiology is clear. Many prolongevity effectors regulate mitochondrial activity and turnover and affect endogenous antioxidant activities that seems to be coordinated with metabolism. The role of coenzyme Q and its enzymatic-dependent activities is important in this regulation and in the progression of aging and is the current focus of research. This research has produced 90 international publications, around 20 book chapters and more than 200 contributions to congresses including invited conferences.
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