It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer.
TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.
Mục lục
Phylogeny of the TRAF/MATH Domain.- TRAF1 and Its Biological Functions.- Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5.- TRAF3 and Its Biological Function.- TRAF4, the Unique Family Member.- Characteristics and Biological Functions of TRAF6.- Ubiquitination and TRAF signaling.- Structural Revelations of TRAF2 Function in TNF Receptor Signaling Pathway.- Protein-Protein Interactions in TRAF3.- Molecular Basis for the Unique Specificity of TRAF6.- TRAF Proteins in CD40 Signaling.- TRAFs in RANK Signaling.- The LT?R Signaling Pathway.- LMP1 TRAFficking Activates Growth and Survival pathways.- Targeting TRAFs for Therapeutic Intervention.
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