NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists.
This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly ‘Idea to Lead’ then ‘Lead to Drug Candidate’, followed by ‘Clinical Development’, and finally ‘Drug Manufacture’. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies.
Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes.
About e Mag Res Handbooks
e Mag Res (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of e Mag Res Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of e Mag Res articles. In consultation with the e Mag Res Editorial Board, the e Mag Res handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.
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Mục lục
1 Drug Discovery and Development: The Role of NMR
2 Modern NMR Pulse Sequences in Pharmaceutical R & D
3 Experimental NMR Methods for Pharmaceutical Research and Development
4 19F NMR spectroscopy: applications in pharmaceutical studies
5 Quantitative NMR Spectroscopy in Pharmaceutical R & D
6 High-throughput NMR in Pharmaceutical R & D
7 Multivariate Data Analysis methods for Pharmaceutical NMR
8 The Role of NMR in Target Identification & Validation for Pharmaceutical R & D
9 High Resolution MAS NMR of Tissues and Cells
10 NMR Studies of Inborn Errors of Metabolism.
11 NMR-Based Structure Confirmation of Hits & Leads in Pharmaceutical R & D
12 Fragment-based drug design using NMR methods
13 Hit Discovery from Natural Products in Pharmaceutical R & D
14 NMR-Based Structure Determination of Drug Leads and Candidates
15 Mixture Analysis in Pharmaceutical R & D using Hyphenated NMR Techniques
16 Conformation and Stereochemical Analysis of Drug Molecules
17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive Compounds
18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety
19 Pre-clinical Drug Metabolism using NMR
20 Pre-clinical Drug Efficacy and Safety using NMR Spectroscopy
21 Characterization of Pharmaceutical Compounds by Solid-State NMR
22 Structure-based Drug Design using NMR
23 Pharmaceutical Technology Studied by MRI
24 NMR-Based Metabolic Phenotyping for Disease Diagnosis & Stratification
25 NMR-Based Pharmacometabonomics: A New Approach to Personalised Medicine
26 Clinical MRI Studies of Drug Efficacy & Safety
27 The Role of NMR in the Protection of Intellectual Property in Pharmaceutical R&D
28 Analysis of counterfeit medicines and adulterated dietary supplements by NMR
29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy
30 NMR Spectroscopy in the European & US Pharmacopoeias
31 NMR in Pharmaceutical Manufacturing
Giới thiệu về tác giả
Jeremy R. Everett, Ph.D., Department of Pharmaceutical, Chemical & Environmental Sciences, University of Greenwich, UK
John C. Lindon, Ph.D., Imperial College London, UK
Ian D. Wilson, Ph.D., Imperial College London, UK
Robin Harris, Ph.D., Department of Chemistry, University of Durham, UK
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