Understanding the play between heredity and environment, and
relating it to disease causation, is the task of ecogenetics.
Gene-Environment Interactions: Fundamentals of Ecogenetics presents
the first comprehensive survey of this discipline, reflecting its
relationship with toxicology, epidemiology, pharmacology, public
health, and other medical and biological fields.
Divided into four sections, the text elucidates key basic and
advanced topics:
* Section 1 covers fundamentals, including the history of the
discipline, a discussion of the molecular laboratory tools
currently available to assess genotypes, using such measurements in
molecular epidemiology studies, and the statistical issues involved
in their analysis.
* Section 2 focuses on a number of key genetic polymorphisms
relevant for ecogenetics, including enzymes of phase I and phase II
metabolism, enzymes involved in DNA repair, as well as receptors
and ion channels. This highlights characteristics of selected,
widely studied genotypic/phenotypic differences, and allows
discussion of how given genetic variations can influence responses
to exogenous chemicals.
* Section 3 examines gene-environment interactions through a
disease-based approach, addressing how genetic polymorphisms can
influence susceptibility to various diseases. Chapters cover
important disease conditions such as various types of cancer,
neurodegenerative diseases, cardiovascular disease, chronic
pulmonary diseases, infectious diseases, diabetes, and
obesity.
* The final section discusses the ethical, legal, and social issues
that arise when investigating and evaluating genetic polymorphisms
in human populations, as well as the impact of ecogenetics on risk
assessment, regulatory policies, and medicine and public
health.
Packed with clear examples illustrating concepts, as well as
numerous tables and figures, Gene-Environment Interactions:
Fundamentals of Ecogenetics is a unique resource for a wide range
of physicians, students, and other specialists.
Mục lục
Foreword.
Acknowledgments.
Contributors.
PART I.
Chapter 1. Introduction (Lucio G. Costa and David L. Eaton).
Chapter 2. Ecogenetics: Historical Perspectives (Gilbert S.
Omenn and Arno G. Motulsky).
Chapter 3. Tools of Ecogenetics (Theo K. Bammler, Federico M.
Farin, and Richard P. Beyer).
Chapter 4. Epidemiologic Approaches (Harvey Checkoway, Parveen
Bhatti, and Anneclaire De Roos).
Chapter 5. Statistical Issues in Ecogenetic Studies (Stephanie
A. Monks).
PART II.
Chapter 6. Overview of Section II (Lucio G. Costa and David L.
Eaton).
Chapter 7. Polymorphisms in Cytochrome P450 and
Flavin-Containing Monooxygenase Genes (Catherine K.Yeung, Allan E.
Rettie, and Kenneth E. Thummel)
Chapter 8. Polymorphisms in Xenobiotic Conjugation (Helen E.
Smith, David L. Eaton, and Theo K. Bammler).
Chapter 9. Paraoxonase, Butyrylcholinesterase, and Epoxide
Hydrolase (Lucio G. Costa, Toby B. Cole, Gary K. Geiss, and Clement
E. Furlong).
Chapter 10. DNA Repair Enzymes (Jon P. Anderson and Lawrence A.
Loeb).
Chapter 11. Receptors and Ion Channels (Lucio G. Costa).
PART III.
Chapter 12. Overview of Section III (Lucio G. Costa and David L.
Eaton).
Chapter 13. Lung Cancer (Valle Nazar-Stewart).
Chapter 14. Gastrointestinal Cancers (Thomas L.Vaughan).
Chapter 15. Neurodegenerative Diseases (Samir N. Kelada, Harvey
Checkoway, and Lucio G. Costa).
Chapter 16. Cardiovascular Disease (Melissa A.Austin and Stephen
M. Schwartz).
Chapter 17. Type 2 Diabetes (Karen L. Edwards).
Chapter 18. Infectious Disease Ecogenetics (David R.
Sherman).
Chapter 19. Genetic Variation, Diet, and Disease Susceptibility
(Johanna W. Lampe and John D. Potter).
Chapter 20. Genetic Determinants of Addiction to Alcohol,
Tobacco, and Drugs of Abuse (Andrew J. Saxon).
PART IV.
Chapter 21. Overview of Section IV (Lucio G. Costa and David L.
Eaton).
Chapter 22. Ethical Issues in Ecogenetics (Kelly Fryer-Edwards,
Lindsay A. Hampson, Christopher R. Carlsten, and Wylie Burke).
Chapter 23. Social and Psychological Aspects of Ecogenetics
(Deborah Bowen, Shirley Beresford, and Brenda Diergaarde).
Chapter 24. Legal Issues (Kate Battuello and Anna
Mastroianni).
Chapter 25. Risk Assessment and the Impact of Ecogenetics
(Elaine M. Faustman and Gilbert S. Omenn).
Bibliography.
Index.
Giới thiệu về tác giả
Lucio G. Costa, Ph.D., is professor of environmental health
and toxicology at the University of Washington School of Public
Health and Community Medicine. He is also director of the
NIEHS-sponsored Neurotoxicology Research Core at the Center in
Ecogenetics and Environmental Health. His research is focused on
the study of the cellular, biochemical and molecular mechanisms
involved in neurotoxicity using biochemical, molecular and imaging
techniques.
David L. Eaton is Professor of Environmental Health and
Associate Dean for Research in the School of Public Health and
Community Medicine at the University of Washington. He serves as
Director of the Center for Ecogenetics and Environmental Health,
and is also Deputy Director for a major NIEHS-sponsored research
initiative in the area of toxicogenomics. Dr. Eaton’s research
interests focus on understanding how subtle genetic differences
between individuals and species can result in potentially large
differences in susceptibility to chemical carcinogens.
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