This book brings together most up-to-date information on different aspects of brain aging and on the strategies for intervention and therapy of age-related brain disorders. It includes 18 chapters by leading researchers, and each chapter is a comprehensive and critical review of the topic in question, discusses the current scenario and focuses on future perspectives. The target readership is the undergraduate and graduate students in the universities, in medical and nursing colleges, along with the post-graduate researchers and practicing clinicians who would like to know about the latest developments in the field of neurodegenerative disorders and their therapeutic interventions. This book will be of much interest to pharmaceutical, nutrition and healthcare industry for an easy access to accurate and reliable information in the field of aging research and intervention.
Mục lục
Editorial.- Contributors.- 1 Brain aging: a critical reappraisal.- 2 Base excision DNA repair: the house keeping guardian for genomic stability in the brain.- 3 Role of brain-derived neurotrophic factor as a modulator of synaptic plasticity.- 4 Mitochondrial dysfunction in sporadic Alzheimer’s disease: mechanisms, consequences and interventions.- 5 Brain Aging: Influence of early–life events on late-life brain disorders.- 6 The importance of the environment in brain aging: Be happy, live longer.- 7 Consequences of altered mortalin expression in control of cell proliferation and brain function.- 8 Age induced alterations in biological clock : Therapeutic effects of melatonin changes in regulation of biological clock.- 9 Neurolipofuscin in aging and aluminum-induced aging: Possible therapeutic interventions.- 10 Dietary restriction as a potential intervention to retard age-associated impairment of brain functions.- 11 Understanding mechanism of action of herbal drugs in age-related degenerative brain disorders.- 12 Neurodegeneration in hypoxia: implications in aging.- 13 Stress and memory; from mechanisms to long-lasting consequences.- 14 Estrogen mediated neuroprotection: Hope to combat neuronal degeneration and synaptic plasticity post-menopause.- 15 Potential therapeutic targets for memory impairments and dementia: Clues obtained from memory-enhanced mice.- 16 Potential beneficial effects of a diet with walnuts in aging and Alzheimer’s disease.- 17 Smart dietary interventions and prevention of cognitive decline with aging.- 18 Herbal cognitive enhancers: New developments and challenges for therapeutic applications.- Index.
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