This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression.
Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease.
Mục lục
1. Role of DNA methylation in the progression and clearance of cancer.- 2. Epigenetical role for RNA in cancer progression.- 3. Epigenetics and its role in prostate cancer.- 4. Epigenetics and ovarian cancer.- 5. Epigenetics and breast cancer.- 6. Epigenetics and thyroid cancer.- 7. Epigenetics and intestinal cancer.- 8. Epigenetics and lung cancer.- 9. Epigenetics and renal cancer.- 10. Epigenetics and cervical cancer.- 11. Epigenetical markers in cancer.- 12. Epigenetical role in pancreatic cancer.
Giới thiệu về tác giả
Manoj K. Mishra, Ph.D., is Associate Professor of Biology and founding Director of the cancer biology research and training program at Alabama State University. He has published over 25 articles, over 30 abstracts and poster exhibits, co-edited a book on Gene Regulation and Cancer, and has written over 5 book chapters. Dr. Mishra is on multiple ed boards, including the European Journal of Bioinformatics, Advances in Medical Informatics, and the International Journal of Experimental Medicine, to name a few.
Kumar S. Bishnupuri, Ph.D., is a Research Instructor in the Department of Medicine at Washington University School of Medicine. Dr. Bishnupuri has published over 16 articles, 4 book chapters, and 32 abstracts for conference symposia. He also serves as a scientific reviewer for several journals including Carcinogenesis, Frontiers in Bioscience, Cancer Biology and Therapy, Journal of Pathology, and more.
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