This book constitutes the refereed proceedings of the 18th International Semantic Web Conference, ESWC 2021, held virtually in June 2021.The 41 full papers and 2 short papers presented were carefully reviewed and selected from 167 submissions. The papers were submitted to three tracks: the research track, the resource track and the in-use track. These tracks showcase research and development activities, services and applications, and innovative research outcomes making their way into industry. The research track caters to both long-standing and emerging research topics in the form of the following subtracks: ontologies and reasoning; knowledge graphs (understanding, creating, and exploiting); semantic data management, querying and distributed data; data dynamics, quality, and trust; matching, integration, and fusion; NLP and information retrieval; machine learning; science data and scholarly communication; and problems to solve before you die.