This book constitutes the refereed proceedings of the Workshop on E-Business (We B 2015), held in Fort Worth, Texas, USA, on December 12, 2015. The theme of We B 2015 was "Leveraging Service Computing and Big Data Analytics for E-Commerce", and thus the workshop provided an interactive forum by bringing together researchers and practitioners from all over the world to explore the latest challenges of next-generation e-Business systems and the potential of service computing and big data analytics.The 11 full and 17 short papers, which were selected from 45 submissions to the workshop, addressed a broad coverage of technical, managerial, economic, and strategic issues related to e-business, with emphasis on service computing and big data analytics. They employed various IS research methods such as case study, survey, analytical modeling, experiments, computational models, and design science.